Results 61 to 70 of about 7,251,508 (263)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Need for and practical interpretations of the person-year construct in neuropsychiatric research
Indian Journal of Psychological Medicine, 2019 In observational studies, groups of interest may be carved out of predictors of interest. Thus, for example, if cardiovascular (CVS) health at age 50 years is the predictor of interest for dementia as the long-term outcome, groups of interest could ...
Chittaranjan Andrade
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Motivational interest of women of 30-50 years old to the studying of healthy exercises [PDF]
Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2011 This article shows the actual problem, which is not so frequently in the publications of scientific-methodical literature, namely, the identification of motivations to attend to fitness physical exercises women of 30-50 years old.
Sorokina S.O., Kudryashova T.I.
doaj
Psychological and organisational aspects of age management in organisations
Management, 2017 In article we present selected issues of age management in organizations. They pointed to the lack of rationale for the discriminatory policies of some companies to employees aged 50+.
Witkowski Stanisław A., Bartosz Bogna
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Атеросклероз, 2017 The aim of the work is to develop a new atherogenic coefficient as a personalized method for assessing cardiovascular risk in patients with dyslipidemia. Materials and methods. The subject of the study was a sample of men and women ( n = 100 people) with
L. D. Latyntseva +3 more
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Cultural Studies und kritische Pädagogik
MedienPädagogik: Zeitschrift für Theorie und Praxis der Medienbildung, 2004 Der Autor stellt die Cultural Studies als transdisziplinäre Forschungsrichtung vor, die in den 50er Jahren in Großbritannien begründet wurde. Diese orientieren sich an alltäglichen Lebenswelten, "Kultur" bezeichnet ein Netzwerk von gesellschaftlichen ...
Rainer Winter
doaj +1 more source