Results 161 to 170 of about 3,253,670 (325)

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

Molecular Oncology, Volume 19, Issue 4, Page 1244-1264, April 2025.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

Reputation shortcoming in academic publishing. [PDF]

PLoS One
Neveu R, Neveu A.
europepmc   +1 more source

（書評）「List of Books and Articles on Law and Politics (1951)(J.S.R.No.3.) Legal History邦譯」

, 1953

openalex   +2 more sources

Preservation of Biscuit and other Farinaceous Articles of Diet from Weevil, Maggots, and other Insects in H.M. Navy [PDF]

, 1875
W. E. Seccombe
openalex   +1 more source

Article [PDF]

Nordic Studies on Alcohol and Drugs, 1997
openaire   +2 more sources

Unraveling epigenetic heterogeneity across gastrointestinal adenocarcinomas through a standardized analytical framework

Molecular Oncology, Volume 19, Issue 4, Page 1117-1131, April 2025.
This study shows that patients with gastrointestinal adenocarcinomas can be stratified into six distinct subtypes based on genome‐scale DNA methylation profiling. This stratification, achieved using a robust analytical framework, aligns with established tumor characteristics and holds potential to support prognostication.
Rita Pinto, Hege Marie Vedeld, Guro Elisabeth Lind, Marine Jeanmougin   +3 more
wiley   +1 more source

Adverse childhood experiences and suicidality in low-income and middle-income countries: a systematic review and meta-analysis. [PDF]

BMJ Glob Health
Blair DL, Kingsbury M, Eccles H, Akther A, Siddiqi S, Condran G, Obeegadoo I, Murray J, Geoffroy MC, Menezes AMB, Sikora L, Colman I.   +11 more
europepmc   +1 more source

Subject Index of Original Articles

, 1953

openalex   +1 more source

Scientific Journals and Articles [PDF]

, 1911
Charles A. Stewart
openalex   +1 more source

The CDK12–BRCA1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence

Molecular Oncology, Volume 19, Issue 4, Page 1265-1280, April 2025.
Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores, Diego M. Fernández‐Aroca, Cristina Garnés‐García, Andrés Domínguez‐Calvo, Jaime Jiménez‐Suárez, Sebastià Sabater, Pablo Fernández‐Aroca, Ignacio Andrés, Francisco J. Cimas, Guillermo de Cárcer, Borja Belandia, Ignacio Palmero, Pablo Huertas, María José Ruiz‐Hidalgo, Ricardo Sánchez‐Prieto   +14 more
wiley   +1 more source