Results 151 to 160 of about 1,191,153 (233)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Population-oriented health promotion and disease prevention interventions in primary healthcare: a scoping review of reviews. [PDF]

BMC Prim Care
Eriksson L, Olsson K, Hasson H, Bergström A, Costea VA, Holm E, Bäck A.   +6 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Effects of Social Prescribing for Older Adults: An Evidence and Gap Map. [PDF]

Campbell Syst Rev
Ghogomu ET, Welch V, Yaqubi M, Dewidar O, Barbeau V, Dowling S, Li Y, Sabri H, Elmestekawy M, Aljufri E, Aliyar B, Pan Y, Al Ameer A, Al Zubaidi A, Bondok M, Kojan W, Madani MT, Tong K, Irefin A, Rampersad IR, Tsai Z, Jahel F, Biswas S, Card KG, Hsiung S, Muhl C, Nelson MLA, Salzwedel DM, Saragosa M, Yu C, Mulligan K, Hébert P.   +31 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Epithelial-Myoepithelial Carcinoma of Minor Salivary Glands of the Palate: A Systematic Review. [PDF]

Health Sci Rep
Khattab NM, Seveyrat R, Taihi I.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Financial well-being advice delivered within the context of social prescribing in the UK and the Republic of Ireland. [PDF]

Front Public Health
Newstead S, Jesurasa A, Jenkins B, Filipponi T, Oloidi E, Makanjuola A, Wallace C.   +6 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Understanding the impact of social determinants of health in hematology: a scoping review of trends across journals and over time. [PDF]

Blood Adv
Lu B, Troyer J, Krause KJ, Lapite A, Aviles M, Della-Moretta S, Dobson D, Farrokhi K, Hasanali ZS, Pillai P, Taborda C, Villagomez L, Vo PT, Wang'ondu RW, Yui JC, Weyand AC, Fingrut WB.   +16 more
europepmc   +1 more source