Results 51 to 60 of about 4,144,457 (271)

Global burden of human brucellosis : a systematic review of disease frequency [PDF]

, 2012
BACKGROUND: This report presents a systematic review of scientific literature published between 1990-2010 relating to the frequency of human brucellosis, commissioned by WHO.
A El Sherbini, A Yacoub, AA Haghdoost, Anna S. Dean, B Bonfoh, B Hernandez, E Jelastopulu, E Schelling, Esther Schelling, F De Massis, F Roth, FK Al-Ani, G Marder, G Pappas, GJ Jennings, Helena Greter, Hélène Carabin, I Avdikou, J Ariza, J Zinsstag, J Zinsstag, JA Al Tawfiq, JA Crump, Jakob Zinsstag, KE Elbeltagy, Lisa Crump, M Minas, MA Al Sekait, MA Idris, MR Hosseini, MR Khorasgani, N Gargouri, O Karabay, QM Abu Shaqra, R Awad, S Vancelik, SA Dahouk, SM Alavi, SR Alballa, TJ Doyle, Z Cetinkaya   +40 more
core   +4 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Level of adherence to prescribed exercise in spondyloarthritis and factors affecting this adherence: a systematic review [PDF]

, 2019
Adherence is a primary determinant of the effectiveness of any intervention. Exercise is considered essential in the management of spondyloarthritis (SpA); however, the overall adherence to exercise programmes and factors affecting adherence are unknown.
Coulter, EH, McDonald, DA, McDonald, MT, Paul, L, Siebert, S   +4 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Challenges in Transcribing Multimodal Data: A Case Study [PDF]

, 2017
open2siComputer-mediated communication (CMC) once meant principally text-based communication mediated by computers, but rapid technological advances in recent years have heralded an era of multimodal communication with a growing emphasis on audio and ...

core  

Using self-categorization theory to uncover the framing of the 2015 Rugby World Cup: a cross-cultural comparison of three nations’ newspapers [PDF]

, 2017
Research into the framing of sporting events has been extensively studied to uncover newspaper bias in the coverage of global sporting events. Through discourse, the media attempt to capture, build, and maintain audiences for the duration of sporting ...
Billings, Andrew C., Harris, John, Scott, Olan Kees Martin, Vincent, John   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

SciTech News- 68(4)-2014 [PDF]

, 2014
Columns and Reports From the Editor 5 SciTech News Call for Articles 5 Conference Report, Diane K. Foster International Student Travel Award Recipient 8 Conference Report, S.

core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source