Results 321 to 330 of about 447,945 (376)

Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis

Med Research, EarlyView.
The review identifies glucocorticoid‐induced osteocyte/osteoblast apoptosis as central to femoral head osteonecrosis (GION), mediated through STAT1‐caspase‐3, PI3K/Akt, Wnt/β‐catenin, and oxidative stress pathways. Emerging therapies targeting these pathways (e.g., HIF‐1α stabilization, AMPK activation, and exosome‐mediated miRNA delivery) show ...
Xiumei Tang, Yanyun Pang, Peijia Zhu, Zhengdong Zhang, Sen Guo, Zhijian Wei, Wenzhao Wang, Bin Ning   +7 more
wiley   +1 more source

Quadruple‐refocused spin‐locking: A robust method for high‐amplitude T1ρ imaging

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose Longitudinal relaxation time in the rotating frame (T1ρ) is a source of tissue‐specific contrasts, with applications in detecting myocardial fibrosis, liver fibrosis, and early‐stage osteoarthritis. However, T1ρ measurements are sensitive to static (B0) and radiofrequency (B1) magnetic field inhomogeneities.
Cai Wan, Maximilian Gram, Wei He, Zheng Xu, Qingping Chen, Sebastian Littin, Thomas Lange, Maxim Zaitsev   +7 more
wiley   +1 more source

The Design and Development of a Dexamethasone‐Tranfersome‐PF‐127/HA Stimuli‐Responsive Hydrogel for Intra‐Articular Therapy in Osteoarthritis

Nano Select, EarlyView.
A dexamethasone‐loaded transfersome‐based hydrogel was developed for sustained intra‐articular delivery in osteoarthritis. The system showed nanoscale particles size, high drug loading capacity, and shear‐thinning behavior. It enabled smooth injection, self‐healing, and prolonged drug release for up to 6 weeks.
Atang Motaung, Thankhoe A. Rants'o, Ravindra V. Badhe, Khonzisizwe Somandi, Yahya E. Choonara   +4 more
wiley   +1 more source

A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine. [PDF]

Osteoarthritis Cartilage
Walton BL, Shattuck-Brandt R, Hamann CA, Tung VW, Colazo JM, Brand DD, Hasty KA, Duvall CL, Brunger JM.   +8 more
europepmc   +1 more source

Water‐in‐oil emulsion templating of isocyanates: end‐capping, foaming, porous structures and cell growth

Polymer International, EarlyView.
Emulsion‐templated and foamed highly interconnected, porous, biodegradable poly(urethane urea) monoliths from isocyanate end‐capped polyols (polycaprolactone or polylactide) or a lysine‐derived diisocyanate exhibited cell growth with potential for tissue engineering applications.
Dganit David, Dekel Rosenfeld, Samah Saied‐Ahmad, Shulamit Levenberg, Michael S. Silverstein   +4 more
wiley   +1 more source

Dual-Contrast Agent with Nanoparticle and Molecular Components in Photon-Counting Computed Tomography: Assessing Articular Cartilage Health. [PDF]

Ann Biomed Eng
Paakkari P, Inkinen SI, Jäntti J, Tuppurainen J, Fugazzola MC, Joenathan A, Ylisiurua S, Nieminen MT, Kröger H, Mikkonen S, van Weeren R, Snyder BD, Töyräs J, Honkanen MKM, Matikka H, Grinstaff MW, Honkanen JTJ, Mäkelä JTA.   +17 more
europepmc   +1 more source

Implication of region-dependent material properties of articular cartilage in the contact mechanics of porcine knee joint. [PDF]

BMC Musculoskelet Disord
Hamsayeh Abbasi Niasar E, Li L.
europepmc   +1 more source

Blackish Discoloration of Articular Cartilage during Total Knee Replacement; a Case Report. [PDF]

J Orthop Case Rep
Puthanveetil DE, Subhash VP, Kannu AN, Kavalakkatt K.   +3 more
europepmc   +1 more source

The mitochondrial protectant SS31 optimized decellularized Wharton's jelly scaffold improves allogeneic chondrocyte implantation-mediated articular cartilage repair. [PDF]

J Orthop Translat
Wang C, Li H, Li F, Yang Y, Xu Z, Gao T, Li R, Zhang R, Mu Y, Guo Z, Guo Q, Liu S.   +11 more
europepmc   +1 more source