Results 91 to 100 of about 165,314 (216)

p21‐Activated Kinase 1 (Pak1) as an Element in Functional and Dysfunctional Interplay Among the Myocardium, Adipose Tissue, and Pancreatic Beta Cells

open access: yesComprehensive Physiology, Volume 15, Issue 2, April 2025.
Pak1 regulates cardiac function, adipose tissue metabolism, and pancreatic β‐cell survival and function. Inflammation, oxidative stress, and Hippo signaling link Pak1 dysfunction across these tissues. Pak1 activators hold promise as potential therapeutic interventions. Images were created with a licensed version of BioRender.com.
Paola C. Rosas, R. John Solaro
wiley   +1 more source

Progression and prognostic significance of electrocardiographic findings in patients with cardiac amyloidosis

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 809-818, April 2025.
Abstract Aims This study aimed to evaluate the change of the main electrocardiographic (ECG) characteristics and their prognostic role across the main subtypes of cardiac amyloidosis [light‐chain amyloidosis (AL) and hereditary (ATTRv) and wild‐type transthyretin amyloidosis (ATTRwt)].
Alessia Argirò   +20 more
wiley   +1 more source

Perforation of the Interventricular Septum by a Temporary Transvenous Pacing Lead Detected by Cardiac Point of Care Ultrasound (POCUS)

open access: yesPOCUS Journal
Several complications can arise during or shortly after the placement of a temporary transvenous pacemaker (TTP), some of which can be potentially devastating.
Pablo Blanco, Liliana Figueroa
doaj   +1 more source

Quantitative aspects of L-type calcium currents [PDF]

open access: yesarXiv, 2011
Calcium currents in neurons and muscle cells have been classified as being one of 5 types of which four, L, N, P/Q and R were said to be high threshold and one, T, was designated low threshold. This review focuses on quantitative aspects of L-type currents.
arxiv  

eGFR slope as predictor of mortality in heart failure patients

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1217-1226, April 2025.
Abstract Aims Heart failure (HF) leads to an imbalance between heart and kidney function, resulting in poor outcomes. However, the prognostic significance of the estimated glomerular filtration rate (eGFR) trajectory in HF patients remains unclear. We analysed electronic health records (EHRs) of real‐world HF patients, assessing eGFR trajectories and ...
Sofie Verstreken   +10 more
wiley   +1 more source

A theory for the membrane potential of cells [PDF]

open access: yesarXiv, 1997
We give an explicit formula for the membrane potential of cells in terms of the intracellular and extracellular ionic concentrations, and derive equations for the ionic currents that flow through channels, exchangers and electrogenic pumps based on simple energy considerations and conservation laws.
arxiv  

A Theory for the Membrane Potential of Living Cells [PDF]

open access: yesarXiv, 1998
We give an explicit formula for the membrane potential of cells in terms of the intracellular and extracellular ionic concentrations, and derive equations for the ionic currents that flow through channels, exchangers and electrogenic pumps. We demonstrate that the work done by the pumps equals the change in potential energy of the cell, plus the energy
arxiv  

Heart rate response to transient hypoxia in patients with heart failure and Cheyne–Stokes respiration

open access: yesExperimental Physiology, Volume 110, Issue 4, Page 532-542, 1 April 2025.
Abstract Cheyne–Stokes respiration (CSR), a rhythmic rise and fall in ventilation often experienced by patients with heart failure during sleep, is typically accompanied by an oscillation in heart rate (HR) at the same frequency. The mechanisms responsible for this oscillation are still debated.
Gian Domenico Pinna   +3 more
wiley   +1 more source

Studying ECG signals using nonlinear oscillators and Genetic Algorithm [PDF]

open access: yesarXiv
Cardiovascular diseases are the leading cause of death and disability in the world and thus their detection is extremely important as early as possible so that it can be prognosed and managed appropriately. Hence, electrophysiological models dealing with cardiac conduction are critically important in the field of interdisciplinary sciences. The primary
arxiv  

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