Results 81 to 90 of about 2,766,273 (253)
Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies [PDF]
, 2009 To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS ...Rice, K. (Kenneth), Samani, NJ, Jamshidi, Yalda, Chris Wallace (210182), Tobin, M., Carter, Nicholas D., Panos Deloukas, Sanna, Serena, DCCT EDIC Res Grp, Pfeufer, Arne, Snieder, Harold; id_orcid, Fu, J, Patricia B. Munroe (7588601), de Bakker, PIW, Kenneth Rice, Carter, N.D. (Nicholas), Zheng, DL, Wain, LV, Caulfield, M. (Mark), Fu, Jingyuan, Sanna, S, Arking Dan E., Morris Brown, Steve Jeffery, Andrew D. Paterson, Newhouse, Stephen; id_orcid, Deloukas, P, Fu, J. (Jingyuan), John M. Connell (7588580), Nolte, I.M., Sanna, S., Paul I W de Bakker, Dalageorgou, C., Wallace, C. (Chris), Lathrop, Mark, Serena Sanna, null null, Waggott, D. (Daryl), Rice Kenneth, Ilja M. Nolte, John Connell, QTGEN Consortium, Farrall Martin, Brown, M, Morris Brown (238594), Samani, Nilesh J., de Bakke, Paul I. W., Martin Tobin, Gwilliam, R. (Rhian), Gwilliam Rhian, QTSCD Consortium, Nilesh J. Samani (7579793), Farrall, M, Rhian Gwilliam, Jeffery, S., Wallace Chris, Irina Savelieva (262110), Wallace,C., Arne Pfeufer, Newton-Cheh, Christopher, Harold Snieder (103613), Martin Farrall, Gwilliam, Rhian, Arking, D.E., Soranzo, N, Newhouse, SJ, Jamshidi, YM, Snieder Harold, Louise V. Wain (7588511), Spector, Tim D., Zheng, D. (Dongling), Zeggini, E, Waggott, Daryl, Andrew D Paterson, Fu Jingyuan, Snieder, H., Zheng, Dongling, Newton-Cheh Christopher, Arking, D.E. (Dan), Munroe, PB, de Bakker, Paul I. W., Wallace, C, Arking, DE, Zheng, D., Newton-Cheh, C., Nicholas D. Carter (7588595), Jamshidi Yalda, Fu, Jingyuan; id_orcid, Dongling Zheng, Chris Wallace, Eijgelsheim, Mark, Louise V Wain, Lathrop, M, Caulfield, M., Tim D. Spector (7588592), Zeggini, Eleftheria, Irina Savelieva, Serena Sanna (145737), Stephen J. Newhouse (7588577), Ilja M Nolte, Pfeufer, A., Folkert W. Asselbergs, Daryl Waggott, Zeggini Eleftheria, Carter, N.D., Folkert W Asselbergs, Pfeufer Arne, Dan E Arking, Lathrop, M. (Mark), Wallace, Chris, Mark Eijgelsheim (110185), Samani, N.J., Waggott, D, Mark Eijgelsheim, Stephen J Newhouse, Munroe, P. (Patricia), Harold Snieder, ?, ?, Tobin Martin, Patricia B Munroe, Sanna, Serena; id_orcid, Pfeufer, A, Savelieva, I. (Irina), Gwilliam, R, Soranzo, N., Yalda Jamshidi, Paul I.W. de Bakker (7588583), Mark Lathrop, Fu, JY, Connell, J. (John), Martin D. Tobin (7581161), Chrysoula Dalageorgou, Soranzo, N. (Nicole), Arne Pfeufer (76634), Dominiczak, A, Savelieva, Irina, Rice, Kenneth, Jeffery, Steve, Paterson, Andrew D., The DCCT/EDIC Research Group, Waggott, D., Snieder, H, Steve Jeffery (262137), Wellcome Trust Case Control Consor, Eleftheria Zeggini, Jingyuan Fu, Farrall, M., Bakker, P.I.W. (Paul) de, Patricia B. Munroe, Brown, M., Deloukas Panos, Brown Morris, Fu, J., Spector Tim D., Paterson, AD, Eleftheria Zeggini (21702), Nilesh J. Samani, Jeffery, S, DCCT/EDIC Research Group, Nicholas D Carter, Zeggini, E. (Eleftheria), Rice, K., Savelieva Irina, Farrall, Martin, Wain, L.V., Nolte, Ilja M., Tobin, Martin, Samani Nilesh J., Jamshidi, Y, Newhouse, S.J. (Stephen), Andrew D. Paterson (7588598), Nicole Soranzo (12361), Tim D Spector, Wain, Louise V., Savelieva, I., Spector, T.D. (Timothy), Nolte Ilja M., Nolte, I.M. (Ilja), Rice, K, Ilja M. Nolte (7588574), Martin Farrall (62715), Munroe, Patricia B., Zheng Dongling, Gwilliam, R., Nolte, Ilja M.; id_orcid, Eijgelsheim, M., Soranzo, Nicole, Eijgelsheim, M. (Mark), Eijgelsheim Mark, Paterson Andrew D., Carter Nicholas D., Jingyuan Fu (102399), Savelieva, I, Asselbergs, FW, Sanna Serena, Dan E. Arking, Dalageorgou, Chrysoula, Caulfield, Mark, Jeffery, S. (Steve), Anna Dominiczak (262121), Asselbergs, F.W., Deloukas, P., Pfeufer, A. (Arne), Christopher Newton-Cheh, Newhouse, S.J., Wain, L.V. (Louise), Nicole Soranzo, Farrall, M. (Martin), Paul I. W. de Bakker, Asselbergs, Folkert W., Nicholas D. Carter, Dominiczak, A., Chrysoula Dalageorgou (262115), de Bakker, Paul I.W., Wellcome Trust Case Control Consortium, Yalda Jamshidi (262159), Lathrop Mark, Asselbergs, F.W. (Folkert), Newhouse, Stephen J., Brown, Morris, Caulfield, M, Jamshidi, Y., Dalageorgou, C, Snieder, H. (Harold), Louise V. Wain, Wain Louise V., Dalageorgou, C. (Chrysoula), Munroe, P.B., Brown, M.J. (Morris), Samani, N.J. (Nilesh), Zeggini, E., de Bakker, PI, Caulfield Mark, Anna Dominiczak, Eijgelsheim, M, Jamshidi, Y. (Yalda), Deloukas, Panos, Jeffery, Steve Jeffery, Dominiczak Anna, Tobin, M, Rhian Gwilliam (108263), Newton-Cheh, C, Newhouse Stephen J., Spector, T.D., Folkert W. Asselbergs (7588589), Snieder, Harold, Dongling Zheng (262112), Arking, Dan E., Munroe Patricia B., de Bakker, P.I., Demissie, S. (Serkalem), Dan E. Arking (7588586), Mark J. Caulfield (7588472), Tim D. Spector, Mark Lathrop (17971), Christopher Newton-Cheh (79953), Stephen J. Newhouse, Nolte, IM, Paterson, A.D. (Andrew), Zheng, D, Sanna, S. (Serena), Connell, J, Newton-Cheh, C. (Christopher), Connell John, Jeffery Steve, Tobin, M. (Martin), Mark Caulfield, Panos Deloukas (21564), Carter, ND, de Bakker Paul I. W., Asselbergs Folkert W., Dominiczak, A. (Anna), Soranzo Nicole, Paterson, A.D., Dominiczak, Anna, Spector, TD, Nilesh J Samani, Connell, J., Daryl Waggott (135190), Connell, John, Waggott Daryl, Kenneth Rice (211836), Dalageorgou Chrysoula, de Bakker, Paul, Nolte, IM;Wallace, C;Newhouse, SJ;Waggott, D;Fu, J;Soranzo, N;Gwilliam, R;Deloukas, P;Savelieva, I;Zheng, D;Dalageorgou, C;Farrall, M;Samani, NJ;Connell, J;Brown, M;Dominiczak, A;Lathrop, M;Zeggini, E;Wain, LV;Newton-Cheh, C;Eijgelsheim, M;Rice, K;de Bakker, PI;Pfeufer, A;Sanna, S;Arking, DE;Asselbergs, FW;Spector, TD;Carter, ND;Jeffery, S;Tobin, M;Caulfield, M;Snieder, H;Paterson, AD;Munroe, PB;Jamshidi, Y, Rice, Ken +285 morecore +2 more sourcesNeuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo
Advanced Science, EarlyView.A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot +10 morewiley +1 more sourceA novel dynamic cardiac simulator utilizing pneumatic artificial muscle
, 2013 With the development of methods and skills of minimally invasive surgeries, equipments for doctors' training and practicing are in high demands. Especially for the cardiovascular surgeries, operators are requested to be familiar with the surgical ...Zhou YY(周圆圆), Yan J(闫杰), Li ZJ(李长吉), Li HY(李洪谊), Liu H(刘浩), Li GX(李贵祥) +5 morecore Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation
Advanced Science, EarlyView.Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel +6 morewiley +1 more sourceGenetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]
, 2011 Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)Carsten Schwenke, Matthias Schott, Koch, Alexander, Stefan R Bornstein, Ralf R Schumann, Schott, Matthias, Lutz Hamann, Hamann, Lutz, Bornstein, Stefan R., Schwenke, Carsten, Alexander Koch, Muhammed Kurt, Zacharowski, Kai, Kai Zacharowski, Olaf Boehm, Schumann, Ralf R., Grotemeyer, Dirk, Kurt, Muhammed, Boehm, Olaf, Dirk Grotemeyer +19 morecore +1 more sourceThe IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism
Advanced Science, EarlyView.A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan +14 morewiley +1 more sourceRestricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle [PDF]
, 2005 Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...Lengyel, Csaba Attila, Varró, András, Takács, János, Bogáts, Gábor, Nagy, Zsolt, Lathrop, David A., Biliczki, Péter, Bitay, Miklós, Jost, Norbert, Virág, László, Papp, Gyula +10 morecore +1 more source
