Results 121 to 130 of about 2,675,143 (333)

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

The Future for End-Stage Kidney Disease Treatment: Implantable Bioartificial Kidney Challenge

Applied Sciences
Despite limited organ availability and post-transplant complications, kidney transplantation remains the optimal treatment for End-Stage Kidney Disease (ESKD).
Federico Nalesso, Francesco Garzotto, Leda Cattarin, Elisabetta Bettin, Martina Cacciapuoti, Cristina Silvestre, Lucia F. Stefanelli, Lucrezia Furian, Lorenzo A. Calò   +8 more
doaj   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Nils Alwall and his artificial kidneys: Seventieth anniversary of the start of serial production [PDF]

, 2019
Jan Kurkus, Janusz Ostrowski
openalex   +1 more source

A comparative assessment of artificial intelligence models used for early prediction and evaluation of chronic kidney disease

Decision Analytics Journal, 2023
R. Sawhney, Aabha Malik, Shilpi Sharma, Vipul Narayan   +3 more
semanticscholar   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

Beyond Human Limits: Harnessing Artificial Intelligence to Optimize Immunosuppression in Kidney Transplantation

, 2023
Debargha Basuli, Sasmit Roy
openalex   +2 more sources

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Renal‐targeted exosomes inhibiting miR‐182‐5p for treatment of renal ischemia–reperfusion injury

Bioengineering & Translational Medicine
Renal ischemia–reperfusion injury (IRI) is a significant condition that leads to acute kidney injury, exacerbating the progression of renal failure clinically and affecting the patient's prognosis.
Zepeng Li, Shirui Sun, Zhenting Zhao, Yingcong Guo, Qi He, Mei Yang, Jin Zheng, Jianhui Li, Wujun Xue, Chenguang Ding   +9 more
doaj   +1 more source

Deep learning in renal ultrasound: applications, challenges, and future outlook

Frontiers in Oncology
Kidney disease poses a significant global health burden, often progressing to end-stage renal disease with serious complications. Renal ultrasound, which is real-time, accessible, and noninvasive, serves as a primary imaging tool for evaluating renal ...
Yong Zhang, Yong Zhang, Yao Hou, Tingting Qiu, Yan Zhuang, Ke Chen, Wenwu Ling, Yan Luo, Jiangli Lin   +8 more
doaj   +1 more source