Results 121 to 130 of about 2,095,062 (293)

The National Security Commission on Artificial Intelligence

, 2021
Website documenting the work of the National Security Commission on Artificial Intelligence, including their final report regarding recommendations for advancement and national security related to "artificial intelligence, machine learning, and ...
National Security Commission on Artificial Intelligence (U.S.)
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Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source

In Search of Effective UiO-66 Metal-Organic Frameworks for Artificial Kidney Application. [PDF]

ACS Appl Mater Interfaces, 2021
Dymek K, Kurowski G, Kuterasiński Ł, Jędrzejczyk R, Szumera M, Sitarz M, Pajdak A, Kurach Ł, Boguszewska-Czubara A, Jodłowski PJ.   +9 more
europepmc   +1 more source

Feasibility Constraints and Protective Behavior in Efficient Kidney Exchange [PDF]

We propose a model of Kidney-Exchange that incorporates the main European institutional features. We assume that patients do not consider all compatible kidneys homogeneous and patients are endowed with reservation values over the minimal quality of the ...
Carmelo Rodríguez Álvarez, Antonio Nicoló   +1 more
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Projections of the prevalence of treated end-stage kidney disease in Australia 2012-2020 [PDF]

, 2014
This paper presents national level projections of the number of people receiving kidney replacement therapy for end-stage kidney disease for the period 2012 to 2020.

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Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

Active Osmotic Exchanger for Efficient Nanofiltration Inspired by the Kidney

Physical Review X, 2016
In this paper, we investigate the physical mechanisms underlying one of the most efficient filtration devices: the kidney. Building on a minimal model of the Henle loop—the central part of the kidney filtration—we investigate theoretically the detailed ...
Sophie Marbach, Lydéric Bocquet
doaj   +1 more source

Safety of electrooxidation for urea removal in a wearable artificial kidney is compromised by formation of glucose degradation products. [PDF]

Artif Organs, 2021
van Gelder MK, Vollenbroek JC, Lentferink BH, Hazenbrink DHM, Besseling PJ, Simonis F, Giovanella S, Ligabue G, Bajo Rubio MA, Cappelli G, Joles JA, Verhaar MC, Gerritsen KGF.   +12 more
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source