Results 151 to 160 of about 246,202 (334)

AI‐Guided SERS Defines a Pan‐Cancer Diagnostic Biomarker

open access: yesAdvanced Science, EarlyView.
An AI‐enabled SERS platform integrates automated exosome enrichment with molecular fingerprinting to enable accurate early detection and differential diagnosis of ten common cancers. The system identifies exosomal dATP as a universal Raman biomarker, offering a scalable, noninvasive, and clinically translatable approach for precision oncology ...
Cai Zhang   +15 more
wiley   +1 more source

One‐Step Coaxial 3D Printing of Pre‐Vascularized Skin Organoid Models with ADSC Microspheres for Enhanced Wound Healing

open access: yesAdvanced Science, EarlyView.
A multifunctional vascular bed platform is created using coaxial 3D printing, allowing the one‐step integration of organoid microspheres with perfusable vascular structures. This strategy enables rapid and functional vascularization of organoids to support tissue repair and vascularization, providing a scalable and translationally promising approach ...
Kunrui Wang   +10 more
wiley   +1 more source

The diagnosis of venogenic impotence [PDF]

open access: yes, 1988
Bosch, Ruud J. L. H.   +5 more
core   +1 more source

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

open access: yesAdvanced Science, EarlyView.
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Sunny H. Kim   +8 more
wiley   +1 more source

Experimentation in machine discovery [PDF]

open access: yes
KEKADA, a system that is capable of carrying out a complex series of experiments on problems from the history of science, is described. The system incorporates a set of experimentation strategies that were extracted from the traces of the scientists ...
Kulkarni, Deepak, Simon, Herbert A.
core   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

open access: yesAdvanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao   +14 more
wiley   +1 more source

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