Results 51 to 60 of about 15,079 (260)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Prosper and Pipesim software for modeling of wells equipped with ESP systems [PDF]

Podzemni Radovi
When the pressure at the bottom of the well is insufficient to overcome the total pressure losses from the bottom of the well to the separator, production using reservoir energy is no longer possible, and the well ceases to naturally flow.
Sredojević Aleksandar, Martinović Bojan, Repac Milan D., Jovanović-Sovtić Dino, Ponoćko Ana, Crnogorac Miroslav, Danilović Dušan   +6 more
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Application of Mechanistic Modeling for Gas Lift Optimization: A General Scaling Curve for Variations of Tubing Size to Optimum Gas Injection

Journal of Earth Energy Engineering, 2019
Gas Lift is currently held as one of the most prominent method in artificial lift, proudly operated flawlessly in hundreds of oil wells in Indonesia. However, gas lift optimization is still governed by the exhaustive Gas Lift Performance Curves (GLPC ...
Prasandi Abdul Aziz, Ardhi Hakim Lumban Gaol, Wijoyo Niti Daton, Steven Chandra   +3 more
doaj   +1 more source

A new approach to improving efficiency of gas-lift wells in the conditions of the formation of organic wax deposits in the Dragon field

Journal of Petroleum Exploration and Production Technology, 2020
Gas-lift is one of the artificial methods in which gas is injected down the production casing–tubing annulus and enters the production tubing through a number of gas-lift valves. During the production of a gas-lift well, the injected compressed gas might
Van Thang Nguyen, Mikhail Konstantinovich Rogachev, Aleksandr Nikolaevich Aleksandrov   +2 more
doaj   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Gas-Powered Negative-Pressure Pump for Liquid Unloading in Underground Gas Storage

Applied Sciences
The efficiency of liquid unloading in dewatering wells directly affects the performance of the Liaohe Ma-19 gas storage facility—the first strongly water-flooded depleted reservoir in China converted for storage use. However, existing hydraulic jet pumps
Bing Leng, Xiangyu Meng, Mingtao Liu, Ruihui Hao, Guoyu Wang, Gang Wang, Pengfei Luo, Xiangji Dou, Haiyang He, Yiming Li, Ning Ni   +10 more
doaj   +1 more source