Results 151 to 160 of about 1,603,738 (220)

Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species

open access: yesExperimental Physiology, Volume 111, Issue 10, Page 4659-4687, 1 October 2026.
Abstract Hyperpolarization‐activated, cyclic nucleotide‐gated (HCN) channels are important regulators of cardiac pacemaking and neuronal excitability, yet their temperature dependence has not been compared systematically across mammalian isoforms and species in standardized experimental conditions. Here, we performed a standardized electrophysiological
Rajnish Ranjan   +5 more
wiley   +1 more source

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

open access: yesThe Journal of Physiology, Volume 604, Issue 19, Page 8069-8099, 1 October 2026.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger   +4 more
wiley   +1 more source

Sub-Acute Re-Elevated Pacing Thresholds After Atrial Leadless Pacemaker Implantation. [PDF]

open access: yesJ Cardiovasc Electrophysiol
Wu D   +7 more
europepmc   +1 more source

Deletion of the sodium leak channel NALCN in dopamine neurons alters D2R‐mediated signalling and psychostimulant responsiveness

open access: yesThe Journal of Physiology, Volume 604, Issue 20, Page 8542-8568, 15 October 2026.
Abstract figure legend The sodium leak channel NALCN is an important contributor to the spontaneous pacemaker activity of midbrain dopamine neurons and is required for proper presynaptic D2 autoreceptor signalling at dopaminergic terminals. Conditional deletion of NALCN in dopamine neurons enhances psychomotor sensitization to amphetamine and cocaine ...
Angelina Rogliardo   +16 more
wiley   +1 more source

Pseudopacemaker syndrome (pacemaker syndrome in the absence of artificial pacemaker)

open access: yesТерапевтический архив, 2004
L M Kharash, A I Kinzbrown
doaj  

The last‐step integrator thesis: Heterarchical control of the mammalian gastrointestinal tract

open access: yesThe Journal of Physiology, Volume 604, Issue 20, Page 8323-8344, 15 October 2026.
Abstract figure legend Heterarchy of control of the gastrointestinal tract. The production mechanisms (i.e. epithelial cells and muscles) are shown at the bottom in green. Above them are some of the many mechanisms that provide control inputs to these production mechanisms.
William Bechtel, Leonardo Bich
wiley   +1 more source

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