Results 51 to 60 of about 89,782 (307)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

The use of arts and humanities as an educational approach to addressing anti-Indigenous racism and discrimination in health systems: a scoping review

Humanities & Social Sciences Communications
Arts and humanities have been used for a variety of purposes in health professions education, from mastering skills to social advocacy. Little is known about how this transformative potential is harnessed within Indigenous-focused health curricula.
Carolyn M. Melro, Jyllenna Landry, Tracy Moniz   +2 more
doaj   +1 more source

Arts and Humanities Education: A Systematic Review of Emerging Technologies and Their Contribution to Social Well-Being

Social Sciences
The purpose of this study is to identify the most applied emerging technologies in the field of arts and humanities, exploring their advantages and potential obstacles. The research results aim to contribute to social and cultural well-being by enhancing
Nancy Usca, Mariela Samaniego, Carlos Yerbabuena, Isaac Pérez   +3 more
doaj   +1 more source

An examination of the physical and the digital qualities of humanities research

, 2008
Traditionally humanities scholars have worked in physical environments and with physical artefacts. Libraries are familiar places, built on cultural traditions over thousands of years, and books are comfortable research companions.
Rimmer, J, Buchanan, G, Gow, J., Buchanan, G., Blandford, A, Warwick, C., Gow, J, Warwick, C, Blandford, A., Rimmer, J.   +9 more
core   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

The Master Builders: LAIRAH Research on Good Practice in the Construction of Digital Humanities Projects

, 2007
This paper describes the results of research carried out during the LAIRAH (Log analysis of Internet Resources in the Arts and Humanities) project (http://www.ucl.ac.uk/slais/circah/lairah/) which is based at UCL’s School of Library Archive and ...
Terras, M, Huntington, P, Warwick, C., Galina, I., Pappa, N, Terras, M., Pappa, N., Warwick, C, Galina, I, Huntington, P.   +9 more
core   +1 more source

Personalized Network‐Guided Neuromodulation Enhances Human Working Memory

Advanced Science, EarlyView.
A personalized neuromodulation framework combining individualized functional brain network targeting with real‐time neural decoding is introduced. Using concurrent TMS–fMRI, participant‐specific stimulation targets and optimal frequencies are identified. Only optimal‐frequency stimulation improves working memory across sessions.
Ahsan Khan, Hongming Li, Camille Blaine, Julie Grier, Ethan Hammett, Almaris Figueroa‐Gonzalez, Sarai Garcia, Romain Duprat, Justin Reber, Joseph Deluisi, Christos Davatzikos, Theodore D. Satterthwaite, Yong Fan, Desmond J. Oathes   +13 more
wiley   +1 more source

Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants

Advanced Science, EarlyView.
The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann, Laura M. De Santis, Paul Neering, Christian Boehler, Kirti Sharma, Arno Aarts, Tobias Holzhammer, Rik J. J. van Daal, Patrick Ruther, Maria Asplund, Roxana N. Kooijmans, Pieter R. Roelfsema   +11 more
wiley   +1 more source

The Value of the Creative Arts for People with mental illness or learning disabilities

, 2005
The creative arts are recognised as having a beneficial effect on people with mental illness or learning disabilities. They aid self expression, communication, increase self esteem and confidence, as well as enhancing skills.
Minogue, Virginia
core   +1 more source

Atomic Interlayer Mo–N4 Sites Enable Rapid Charge Transfer and Efficient CO2 Photoreduction

Advanced Science, EarlyView.
This work achieved efficient CO2 activation and ultrafast interlayer electron transport in a 2D COF by constructing atomic‐level Mo‐N4‐induced interlayer electron bridges (IEB), thereby kinetically and thermodynamically co‐driving the photocatalytic coupling of CO2 reduction with 4‐methoxybenzyl alcohol oxidation.
Lijuan Sun, Haiwei Su, Zhen Chen, William Orbell, Guijie Liang, Weikang Wang, Lele Wang, Juan Yang, Qinqin Liu, Junhua Li   +9 more
wiley   +1 more source