Results 131 to 140 of about 123,920,104 (297)

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Discovery of the Cyclic Form of MRI pH‐Sensor Z‐OMPD Enables >5% 13C Hyperpolarization by SABRE

Angewandte Chemie International Edition, EarlyView.
With “c‐OMPD”, we discovered a previously unknown 5‐membered lactol structure that arises from the homoaldol condensation of the central metabolite pyruvic acid. We demonstrate that the cyclization equilibrium is of crucial importance for OMPD's function as MRI‐based pH sensor and achieve for the first time 13C polarization levels (>5%) by SABRE in the
Juanita Ferreira, Ivan A. Trofimov, Martin Grashei, Adriana Sacristán‐Martín, Alexander Huber, David Schleicher, Oleksiy Khavryuchenko, Franz Schilling, Andreas B. Schmidt, Max von Delius   +9 more
wiley   +1 more source

Comparative analysis of complete chloroplast genomes provides insights into phylogenetic relationships and screening of polymorphic markers in Dimocarpus and related species

BMC Plant Biology
Background Longan (Dimocarpus longan) is a highly nutritious subtropical perennial fruit tree that has been used as a traditional medicine since ancient times for its tonic properties.
Yuan Guo, Chong Sun, Han Liu, Chongyu Liu, Yifei Deng, Xia Liu, Xueqian Fu, Ruxin Xu, Mi Kuang, Lingling Peng, Shanrong Li, Dalan Feng, Xiaohong Yang   +12 more
doaj   +1 more source

Preparation of MOEAMCl and MAAm Based Hydrogels and Effective Use in Anionic Dye Adsorption

Journal of Applied Polymer Science, Volume 142, Issue 16, April 20, 2025.
ABSTRACT In this study, hydrogels based on [2‐(Methacryloyloxy)ethyl]trimethylammonium chloride (MOEAMCl) and methacrylamide (MAAm) were synthesized for the removal of anionic dyes from aqueous solutions. Following detailed characterization, the use of hydrogels for methyl orange (MO) adsorption was investigated.
Hilal Nur Duykop Demir, Ali Delibaş, Ayşe Benk, Ramazan Coşkun   +3 more
wiley   +1 more source

Origin, evolution and biogeographic dynamics of the European rabbit (Oryctolagus cuniculus) in Southwestern Europe

The Anatomical Record, EarlyView.
Abstract The Pleistocene is a key period for understanding the evolutionary history and palaeobiogeography of the European rabbit (Oryctolagus cuniculus). The species was first documented in southeastern Iberia at the beginning of the Middle Pleistocene and appears to have rapidly spread throughout Southwestern Europe, where it was found in numerous ...
Maxime Pelletier
wiley   +1 more source

Debate about asessment practices in artistic disciplines

Educación, 2017
This essay presents the debate about assessment practices in artistic disciplines in the context of higher education. It exposes the challenges of assessment in the arts and discusses the necessity to clarify its objectives.
Lucia Ginochio Castro
doaj  

Tracheal chambers as a key innovation for high‐frequency emission in bat echolocation

The Anatomical Record, EarlyView.
Abstract Key innovations are pivotal for biodiversity and facilitating evolutionary success, enabling organisms' adaptation to various ecological niches through the diversification of phenotypic traits. In mammals, notable adaptations include evolving hypsodonty for grazing on grasses and, for bats, evolving echolocation and wing acquisition.
Nicolas L. M. Brualla, Laura A. B. Wilson, Khizar Hayat, Michael Doube, Vuong Tan Tu, Thongchai Ngamprasertwong, Thanakul Wannaprasert, Daisuke Koyabu   +7 more
wiley   +1 more source

Cortical bone geometry and static gravitational loads in neosauropod dinosaurs: Implications for biomechanical constraints on terrestrial gigantism

The Anatomical Record, EarlyView.
Abstract Sauropod dinosaurs achieved unprecedented terrestrial gigantism, raising questions about the biomechanical limits of bone under extreme gravitational loads. We estimated static gravitational pressures (Pg) on appendicular cortical bone in neosauropods, including diplodocoids, brachiosaurids, and titanosaurs.
Tito Aureliano, Aline M. Ghilardi, Holly N. Woodward, Horácio W. L. Alves, Guilherme M. Sipahi   +4 more
wiley   +1 more source

Prace z równań różniczkowych w „Pamiętniku Akademii Umiejętności w Krakowie”

Zagadnienia Filozoficzne w Nauce, 2013
This paper concerns the general characteristics of the Academy of Arts and Sciences in Cracow and the Memoirs of the Academy of Arts and Sciences in Cracow.
Jan Koroński
doaj  

High Rate of Return to Sport in Competitive Athletes Undergoing Periacetabular Osteotomy With Concomitant Hip Arthroscopy

Arthroscopy, EarlyView.
Purpose To report the return‐to‐sport rate of competitive athletes with hip dysplasia, in relation to their preoperative level of competition, who underwent hip arthroscopy with concomitant periacetabular osteotomy (HA + PAO). Methods Patients participating in competitive sports who underwent HA + PAO for the correction of hip dysplasia between January
Alfred Mansour, Nicole Lemaster, Jacob Jelmini, Philip Sheedy, Anota Adekunle, Alexis Aboulafia   +5 more
wiley   +1 more source