The Signaling Nature of Cellular Metabolism: The Hypoxia Signaling [PDF]
, 2018 Identification of the hypoxia-inducible factors (HIFs) as core players of the transcriptional response to hypoxia transformed our understanding of the mechanism underpinning the hypoxic response at the molecular level and led to discoveries on the role ...
Fabian, Zsolt
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Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke [PDF]
, 2013 Neurologic conditions including stroke, Alzheimer disease, Parkinson disease, and Huntington disease are leading causes of death and long-term disability in the United States, and efforts to develop novel therapeutics for these conditions have ...
Basso, Manuela +9 more
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International Journal of Andrology, 2010 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates diverse dioxin toxicities. While the acute effects of activation of the AhR pathway by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been a focus of past study,
O. Jablonska +4 more
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The effect of hypoxia on ER-β expression in the lung and cultured pulmonary artery endothelial cells [PDF]
, 2013 Indiana University-Purdue University Indianapolis (IUPUI)17-β estradiol (E2) exerts protective effects in hypoxia-induced pulmonary hypertension (HPH) via endothelial cell estrogen receptor (ER)-dependent mechanisms. However, the effects of hypoxia on ER
Selej, Mona M.A.
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The genetic analysis of bHLH-PAS genes in Caenorhabditis elegans [PDF]
, 2002 The family of basic-helix-loop-helix-PAS (bHLH-PAS) transcription factors mediate diverse cellular processes. These include several important cell fate decisions and cellular responses to environmental signals.
Jiang, Huaqi
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Xenobiotic exposure under hypoxic conditions in aquatic organisms: Interactions between the signaling routes mediated by the HIF-alfa and AHR transcription factors [PDF]
, 2016 226 p.as rutas moleculares encargadas del metabolismo de xenobióticos y de la adaptación a condiciones de escasez de oxígeno están mediadas respectivamente por el receptor de hidrocarburos arilo (AHR) y el factor 1¿ inducido por hipoxia (HIF-1¿).
Martos Bernal, Josue
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Cobalt chloride, a chemical inducer of hypoxia-inducible factor-1α in U251 human glioblastoma cell line [PDF]
, 2010 Tumor hypoxia has been described to increase the resistance of cancer cells to radiation therapy and chemotherapy. Hypoxia-inducible factor-1α (HIF-1α) is the main transcriptional factor activated by hypoxia and it plays a key role in reprogramming tumor
Al Okail, Majed S.
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Signaling via the bHLH-PAS proteins AhR and HIF [PDF]
, 2012 This thesis concerns some mechanistic properties of the basic helix-loop-helix/PAS (bHLH-PAS) factors aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1 alpha (HIF-1α). The bHLH-PAS family of proteins is a family of factors that controls
Bosdotter, Cecilia
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Control of the Hypoxic Response in Drosophila melanogaster by the Basic Helix-Loop-Helix PAS Protein Similar [PDF]
, 2002 In mammalian systems, the heterodimeric basic helix-loop-helix (bHLH)-PAS transcription hypoxia-inducible factor (HIF) has emerged as the key regulator of responses to hypoxia.
Bocca, Silvia N. +8 more
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Reciprocal Modulation of Hepatic Cytochrome P450 Gene Expressions with Streptozotocin Induced Diabetes and Resveratrol [PDF]
, 2011 Cytochrome P450s are very large and diverse superfamily of hemoproteins found in all domains of life and diverse array of compounds can influence the relative concentrations and/or activities of P450s.
Sadi, Gökhan, Sadi, Özlem
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