Results 21 to 30 of about 3,554 (178)

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

The FEBS Journal, EarlyView.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera, Shiyang Song, Sofia Ylinen, Talha Qureshi, Bin Li, Zhi Chen   +5 more
wiley   +1 more source

Functional and Organic Foods in Enhancing the Oral and Dental Health and Hygiene—A Comprehensive Review

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Functional and organic foods contain effective and bioactive compositions. Organic foods and foods enriched with phytochemicals provide promising oral health. Functional foods and beverages in the diet can control and treat oral illnesses ABSTRACT Maintaining oral and dental hygiene, it is significantly related to individuals' quality of life as well ...
Elahe Aleebrahim‐Dehkordi, Ahmad Sheibaninia, Abdolah Ghasemi Pirbalouti   +2 more
wiley   +1 more source

Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment

Cancer Medicine, Volume 15, Issue 1, January 2026.
Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang, Binle Tian, Jingyi Zhou, Di Ma, Rongze Sun, Qi Li   +5 more
wiley   +1 more source

The Enteric Nervous System as a Mediator of Microbiota‐Gut‐Brain Interactions in Parkinson's Disease

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Parkinson's disease (PD) is a neurodegenerative disorder that is increasingly recognized as a gut‐brain disorder, involving gut dysfunction before the onset of motor symptoms. While many studies have focused on changes in gut microbiota, inconsistent results highlight the limitations of viewing PD through a microbiota‐only lens.
Luisa Valdetaro, Maria Carolina Ricciardi, Patricia Pereira Almeida, Milena Barcza Stockler‐Pinto, Ana Lucia Tavares‐Gomes   +4 more
wiley   +1 more source

Role of Tryptophan Metabolism in Cancer

Cancer Innovation, Volume 4, Issue 6, December 2025.
This review systematically summarizes the functions and related mechanisms of tryptophan metabolism in various tumor types. It presents the latest progress in this field in a comprehensive manner and combines this with clinical practice to offer a new perspective on tumor treatment.
Zhehao Cui, Dandan Wang, Ye Zhang, Long Yuan, Yi Zhang, Xiaowei Qi   +5 more
wiley   +1 more source

Physiological Differences Underlying Divergent Hypoxia Responses and Altitude Adaptations in Humans, Rats and Mice

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
Despite many physiological similarities, mice, rats and humans respond remarkably differently to hypoxia. In line with their high‐altitude phylogeographic history, mice are physiologically well equipped to deal better with high‐altitude hypoxia than humans, while the low‐land origin of rats may be associated with a particularly high vulnerability to ...
Johannes Burtscher, Robert T. Mallet, Anupam Sah, Max Gassmann, Martin Burtscher, Rodrigo Iturriaga   +5 more
wiley   +1 more source

Urinary metabolomic profiling in 22q11.2 deletion syndrome reveals microbial and mitochondrial signatures related to autism and psychosis risk

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Aim 22q11.2 deletion syndrome (22qDS) is the most common copy‐number‐variation disorder, associated with multi‐organ anomalies and elevated risk for schizophrenia and other neuropsychiatric conditions. Previous metabolomic studies have used blood samples, implicating mitochondrial dysfunction and amino acid imbalance, but no urinary ...
Takuto Minami, Tempei Ikegame, Miho Tanaka, Eureka Kumagai, Akiko Kanehara, Ryo Morishima, Yousuke Kumakura, Noriko Okochi, Junko Hamada, Tomoko Ogawa, Hidetaka Tamune, Yukiko Kano, Seiichiro Jinde, Kiyoto Kasai   +13 more
wiley   +1 more source

Omeprazole and aryl hydrocarbon hydroxylases: Should we be worried? [PDF]

Hepatology, 1991
Diaz and colleagues have carefully studied the effects of omeprazole on the expression of cytochrome P-450 in primary cultures of human hepatocytes. When omeprazole was added to the culture medium in varying concentrations, there was an increase in P-450IA2 protein and mRNA concentrations, an increase in de novo synthesis of P-
Kolars, Joseph C., Turgeon, D. K., Watkins, Paul B.   +2 more
openaire   +3 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, John A. Cidlowski, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jane F. Armstrong, O. Peter Buneman, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +51 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source