Results 271 to 280 of about 25,056,579 (316)

Late-Onset Metachromatic Leukodystrophy with Early Onset Dementia Associated with a Novel Missense Mutation in the Arylsulfatase A Gene.

Journal of Alzheimer's Disease, 2016
A 48-year-old male patient presented with personality changes and progressive memory loss over 2 years with initially suspected Hashimoto's encephalopathy.
K. Stoeck, M. Psychogios, A. Ohlenbusch, R. Steinfeld, J. Schmidt   +4 more
semanticscholar   +1 more source

The purification of arylsulfatases A and B

Biochemical Medicine, 1984
Abstract Arylsulfatases A and B (arylsulfate sulfohydrolase, EC 3.1.6.1) are isoenzymatical. Both enzymes are located mainly in the liver, though they are widely distributed in mammalian tissues [rabbit liver (1), ox liver (2), human kidney (3), human brain (4), and human liver (5)].
Kazuo Ohuchi, Mikio Kan, Tsuneo Ozeki, Kikuko Iwaki   +3 more
openaire   +3 more sources

Characterization of an arylsulfatase from a mutant library of Pseudoalteromonas carrageenovora arylsulfatase

International Journal of Biological Macromolecules, 2017
A library of Pseudoalteromonas carrageenovora arylsulfatase mutants was constructed by introducing random mutagenesis using error-prone PCR. After screening, one mutant strain was obtained whose arylsulfatase had improved thermal stability. Protein sequence analysis revealed one amino acid substitution of H260L.
Yanbing Zhu, Chaochao Qiao, Anfeng Xiao, Hui Ni, Zedong Jiang, Han Liu, Lijun Li   +6 more
openaire   +3 more sources

Arylsulfatase of sea urchin sperm—Distribution of arylsulfatase in the gonads and gametes of echinoderms

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1979
1. Fairly high activities of arylsulfatase are found in the sperm and mature testes of all the sea urchins studied; Strongylocentrotus intermedius, Strongylocentrotus nudus, Hemicentrotus pulcherrimus and Anthocidaris crassispina, whereas the activities in the ovaries and eggs of these animals are low. 2.
Tsuneo Moriya, Motonori Hoshi
openaire   +3 more sources

A new analytical bench assay for the determination of arylsulfatase a activity toward galactosyl-3-sulfate ceramide: implication for metachromatic leukodystrophy diagnosis.

Analytical Chemistry, 2014
Here, we present the design and validation of a new assay for the diagnosis of metachromatic leukodystrophy. The method is highly specific, simple, reproducible, and straightforward. In our spectrophotometric method, the determination of arylsulfatase A (
F. Morena, Ilaria di Girolamo, C. Emiliani, A. Gritti, A. Biffi, S. Martino   +5 more
semanticscholar   +1 more source

Arylsulfatase of sea urchin sperm

Developmental Biology, 1980
Abstract An arylsulfatase is defined as a lysin of sea urchin sperm from the following evidences. (1) The activity is detected in the sperm of all the sea urchins investigated, and the activity is partially liberated from the cells after the acrosome reaction ( Moriya and Hoshi, 1979 ).
Tsuneo Moriya, Motonori Hoshi
openaire   +3 more sources

Studies of pH-dependent self-association of a recombinant form of arylsulfatase A with electrospray ionization mass spectrometry and size-exclusion chromatography.

Analytical Chemistry, 2013
Arylsulfatase A is an endogenous enzyme that is responsible for the catabolism and control of sulfatides in humans. Its deficiency results in the accumulation of sulfatides in the cells of the central and peripheral nervous system leading to the ...
R. Abzalimov, Cedric E. Bobst, P. Salinas, P. Savickas, John J. Thomas, I. Kaltashov   +5 more
semanticscholar   +1 more source

A new electrophoretic variant of arylsulfatase A

Biochemical Medicine and Metabolic Biology, 1988
Previous work in this laboratory has identified electrophoretic variant forms of arylsulfatase A in leucocyte plus platelets. During a study to replicate and extend these findings, a new seven-band variant of arylsulfatase A has been identified. Purified platelets gave a clearer, more distinct electrophoretic banding pattern than the leucocyte and ...
Paul Manowitz, Sudhansu Chokroverty, James M. Fazzaro, Peter E. Nathan, Rena Nora, Lu Ann Villano Fine   +5 more
openaire   +3 more sources

The determination of arylsulfatases in biological fluids

Clinica Chimica Acta, 1970
Abstract A simple, highly sensitive method for the determination of arylsulfatases in serum, urine, saliva and other biological fluids is described. A procedure is given for the preparation of highly purified 4-methylumbelliferone sulfate, the substrate used in this assay.
B.J. Haverback, H. Rinderknecht, M.C. Geokas, C. Carmack   +3 more
openaire   +3 more sources

Choroideremia with leukoencephalopathy and arylsulfatase A pseudodeficiency

Journal of the Neurological Sciences, 1996
A 33-year-old male patient was admitted to our hospital because of progressive gait disturbance and involuntary movement of the neck. He showed choroideremia, distal motor neuropathy, and leukoencephalopathy on T2-weighted brain magnetic resonance imaging (MRI).
Satoshi Takenaga, Wataru Matsuyama, Hironobu Kanazawa, Shinji Ijichi, Mitsuhiro Osame, Masaru Kuriyama, Masanori Nakagawa   +6 more
openaire   +3 more sources