Results 291 to 300 of about 25,056,579 (316)
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Late adult metachromatic leukodystrophy. Arylsulfatase A activity of leukocytes in two families.
Archives of Neurology, 1972Arylsulfatase A activity has been determined quantitatively in leukocytes of two unrelated patients with late adult metachromatic leukodystrophy (MLD) (40 and 44 years old) and 29 family members.
H. Pilz
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Pseudodeficiencies of Arylsulfatase A and Galactocerebrosidase Activities
Developmental Neuroscience, 1991Pseudodeficiency is defined as the in vitro measurement of low activity (usually under 15% of the normal mean for controls) of an enzyme in a healthy person. They may be hard to distinguish from presymptomatic people who will present with adult-onset clinical disease.
E Louie, D A Wenger
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, 1971
METACHROMATIC leukodystrophy (MLD) is characterized by deficient activity of sulfatase A (arylsulfatase A; cerebroside sulfatase) and by a corresponding accumulation of cerebroside sulfate.
David A. Stumpf, James H. Austin
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METACHROMATIC leukodystrophy (MLD) is characterized by deficient activity of sulfatase A (arylsulfatase A; cerebroside sulfatase) and by a corresponding accumulation of cerebroside sulfate.
David A. Stumpf, James H. Austin
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Arylsulfatase A Variants in Patients with Alcoholism
Alcoholism: Clinical and Experimental Research, 1984Leukocytes from 200 mentally ill patients and 100 normal controls were analyzed for eiectrophoretic variants of arylsulfatase A. Four different variant forms were found in 15 subjects. There is a relatively high occurrence of the arylsulfatase A variants in patients with alcoholism. Twenty‐one per cent (12/56) of patients with alcoholism have a variant
Atul R. Hulyalkar +2 more
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Arylsulfatase in coelomocytes ofHolothuria polii
Experientia, 1988Holothuria polii coelomocytes possess arylsulfatase enzymes. Two pH optima were found for arylsulfatase activity in cell lysate preparations, one at pH 5.0 and the other at pH 5.8. Both increased after injection of zymosan particles or formalinized sheep red blood cells (fSR-BC), indicating an active role of the enzymes during phagocytosis of ...
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Arylsulfatases of human tissue studies on a form of arylsulfatase B found predominantly in brain
Biochimica et Biophysica Acta (BBA) - Enzymology, 1977The distribution of soluble arylsulfatase (aryl-sulfate sulfohydrolases, EC 3.1.6.1) in human tissues was investigated by DEAE-cellulose chromatography, All tissues examined contained arylsulfatase A and arylsulfatase B. In addition, brain singularly contained significant quantities (15-25% of total arylsulfatase) of a minor anionic arylsulfatase from ...
Audrey R. Killgrove +3 more
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Biochimica et Biophysica Acta (BBA) - Enzymology, 1980
The brain-specific arylsulfatase Bm (aryl-sulfate sulfohydrolase, EC 3.1.6.1) was demonstrable in human and monkey brain. Arylsulfatases A, B and Bm were separated employing DEAE-cellulose chromatography. There was a distinct difference in the proportion of the sulfatases in infant and adult human brain.
A.S. Balasubramanian, S. Lakshmi
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The brain-specific arylsulfatase Bm (aryl-sulfate sulfohydrolase, EC 3.1.6.1) was demonstrable in human and monkey brain. Arylsulfatases A, B and Bm were separated employing DEAE-cellulose chromatography. There was a distinct difference in the proportion of the sulfatases in infant and adult human brain.
A.S. Balasubramanian, S. Lakshmi
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Safety of arylsulfatase A overexpression for gene therapy of metachromatic leukodystrophy.
Human Gene Therapy, 2007Successful gene therapy approaches for metachromatic leukodystrophy (MLD), based either on hematopoietic stem/progenitor cells (HSPCs) or direct central nervous system (CNS) gene transfer, highlighted a requirement for high levels of arylsulfatase A ...
A. Capotondo +12 more
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Human Genetics, 1986
It had been shown previously that arylsulfatase A activity was attenuated in pseudo arylsulfatase A deficiency fibroblasts and that subunits of the enzyme were smaller than subunits of the enzyme in normal fibroblasts. Attenuated enzyme activity has now been affirmed in other tissues.
Arvan L. Fluharty +2 more
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It had been shown previously that arylsulfatase A activity was attenuated in pseudo arylsulfatase A deficiency fibroblasts and that subunits of the enzyme were smaller than subunits of the enzyme in normal fibroblasts. Attenuated enzyme activity has now been affirmed in other tissues.
Arvan L. Fluharty +2 more
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Investigations on the arylsulfatase activity of the human placenta
American Journal of Obstetrics and Gynecology, 1972Abstract Arylsulfatase activity has been shown mainly in combined mitochondrial and postmitochondrial-lysosomal fraction and also in the microsomal fraction of the human placenta. No differences in subcellular distribution of enzymatic activity were found in various periods of development and growth of the placenta.
W.H. Trzeciak, J. Lewicki
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