Results 271 to 280 of about 620,208 (350)

Evaluating the risk of recurrence in neovascular age-related macular degeneration using OCT-angiography at the time of treatment exit. [PDF]

Br J Ophthalmol
Jaggi D, Marugg S, Berger LE, Munk MR, Zinkernagel MS, Heussen FM.   +5 more
europepmc   +1 more source

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

Advanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler, Tim Lange, Sophia‐Marie Bach, Soeren S. Lienkamp, Nicole Endlich   +4 more
wiley   +1 more source

Biomechanical Model of Outer Retinal Corrugations and Bacillary Layer Detachment in Rhegmatogenous Retinal Detachment. [PDF]

Invest Ophthalmol Vis Sci
Varma SC, Martins Melo I, Pecaku A, Sabour S, Ramachandran A, Muni RH.   +5 more
europepmc   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Recognition of Intracranial Hypertension in Children with Craniosynostosis using Handheld OCT: A Diagnostic Accuracy Study

Rufai SR, Purohit R, Bowman R, Gottlob I, Bunce C, Panteli V, Thompson DA, Marmoy OR, Henderson RH, O’Connor J, Thomas MG, Silva AH, James G, Patel CK, Hayward R, Thomas GP, Dunaway DJ, Johnson D, Proudlock FA, Lawrence TP, Jeelani NuO.   +20 more
europepmc   +1 more source

Macular Edema Without Vascular Leakage - The Diagnostic Challenge of SNIFR and its Differential Diagnoses. [PDF]

Klin Monbl Augenheilkd
Näther S, Zweifel S, Gabathuler F, Blaser F, Maloca P, Fasler K.   +5 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Acute onset of neovascular age-related macular degeneration after initiation of tirzepatide. [PDF]

Diabetol Int
Takebayashi K, Iemura Y, Yamauchi M, Hara K, Tsuchiya T, Machida S, Hashimoto K.   +6 more
europepmc   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

A Case Series of Familial Macular Drusen: Clinical, Imaging, and Diagnostic Considerations in the Spectrum Between Age-Related Macular Degeneration (AMD) and Other Macular Disorders. [PDF]

Cureus
Faustine G, Bastion MC.
europepmc   +1 more source