Results 11 to 20 of about 22,367 (166)

Results from a Genome-Wide Association Study (GWAS) in Mastocytosis Reveal New Gene Polymorphisms Associated with WHO Subgroups. [PDF]

Int J Mol Sci, 2020
Mastocytosis is rare disease in which genetic predisposition is not fully understood. The aim of this study was to analyze associations between mastocytosis and single nucleotide polymorphisms (SNPs) by a genome-wide association study (GWAS) approach.
Nedoszytko B, Sobalska-Kwapis M, Strapagiel D, Lange M, Górska A, Elberink JNGO, van Doormaal J, Słomka M, Kalinowski L, Gruchała-Niedoszytko M, Nowicki RJ, Valent P, Niedoszytko M.   +12 more
europepmc   +2 more sources

A Cross-Tissue Transcriptome-Wide Association Study Identified Susceptibility Genes for Intervertebral Disc Degeneration. [PDF]

JOR Spine
This study conducted a cross‐tissue transcriptome‐wide association study (TWAS) integrating data from FinnGen R12 and GTEx v8 to identify susceptibility genes for intervertebral disc degeneration (IDD). Through TWAS, MAGMA analyses, Mendelian randomization, and colocalization analyses, six candidate genes (ADD1, GFPT1, MAPRE3, MSANTD1, SLC30A6, and ...
Zhang L, Zhao W, Yang H, Deng T, Li Y.
europepmc   +2 more sources

Targeting lncRNA DDIT4‐AS1 Sensitizes Triple Negative Breast Cancer to Chemotherapy via Suppressing of Autophagy

Advancement of science, 2023
In this study, it is found that the lncRNA, DNA damage inducible transcript 4 antisense RNA1 (DDIT4‐AS1), is highly expressed in triple‐negative breast cancer (TNBC) cell lines and tissues due to H3K27 acetylation in the promoter region, and promotes the
Ting Jiang, Jiaojiao Zhu, Shi-long Jiang, Zonglin Chen, Ping Xu, Rong Gong, Changxin Zhong, Yu Cheng, Xinyuan Sun, Wen-jun Yi, Jinming Yang, Wenhu Zhou, Yan Cheng   +12 more
semanticscholar   +1 more source

LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis

Cancer Biology & Therapy, 2023
Cisplatin resistance is a major therapeutic challenge in non-small cell lung cancer (NSCLC). Herein, the regulatory role of long non-coding RNA (lncRNA) ITGB2-AS1 in regulating NSCLC cisplatin resistance was investigated. NSCLC cisplatin resistance cells
H. Chen, Linhui Wang, Jingting Liu, Zi-Fen Wan, Lin Zhou, Hong-yin Liao, Renping Wan   +6 more
semanticscholar   +1 more source

Bone marrow mesenchymal stem cell-derived exosomal lncRNA KLF3-AS1 stabilizes Sirt1 protein to improve cerebral ischemia/reperfusion injury via miR-206/USP22 axis

Molecular Medicine, 2023
Background Cerebral ischemia/reperfusion (I/R) is a pathological process that occurs in ischemic stroke. Bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) have been verified to relieve cerebral I/R-induced inflammatory injury.
Xiao-Hui Xie, Yu Cao, Liangping Dai, Dingzhou Zhou   +3 more
semanticscholar   +1 more source

Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m6A-dependent recognition of Nrf2 mRNA mediated by SND1

Journal of experimental & clinical cancer research : CR, 2023
Background Ferroptosis has been linked to tumor progression and resistance to antineoplastic therapy. Long noncoding RNA (lncRNA) exerts a regulatory role in various biological processes of tumor cells, while the function and molecular mechanism of ...
Jianglin Zheng, Qing Zhang, Zhen-Ran Zhao, Y. Qiu, Yu-jie Zhou, Zhipeng Wu, Cheng Jiang, Xuan Wang, Xiaobing Jiang   +8 more
semanticscholar   +1 more source

The Tumorigenic Effect of lncRNA AFAP1‐AS1 is Mediated by Translated Peptide ATMLP Under the Control of m6A Methylation

Advancement of science, 2023
Long noncoding RNAs (lncRNAs) in eukaryotic transcripts have long been believed to regulate various aspects of cellular processes, including carcinogenesis.
Hailong Pei, Yingchu Dai, Yongduo Yu, Jiaxin Tang, Z. Cao, Yongsheng Zhang, Bingyan Li, Jing Nie, T. Hei, Guangming Zhou   +9 more
semanticscholar   +1 more source

Long noncoding RNA DIAPH2-AS1 promotes neural invasion of gastric cancer via stabilizing NSUN2 to enhance the m5C modification of NTN1

Cell Death and Disease, 2023
Neural invasion (NI) is a vital pathological characteristic of gastric cancer (GC), which correlates with tumor recurrence and a worse prognosis. Long noncoding RNAs (lncRNAs) play critical roles in various biological processes.
Y. Li, Yiwen Xia, T. Jiang, Ze-Hao Chen, Yi-cun Shen, Jie Lin, Li Xie, Chao Gu, Jialun Lv, Chen Lu, Diancai Zhang, Hao Xu, Li Yang, Zekuan Xu, Linjun Wang   +14 more
semanticscholar   +1 more source

Multiomics analyses reveal DARS1-AS1/YBX1–controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance

Science Advances, 2023
The glioblastoma (GBM) stem cell–like cells (GSCs) are critical for tumorigenesis/therapeutic resistance of GBM. Mounting evidence supports tumor-promoting function of long noncoding RNAs (lncRNAs), but their role in GSCs remains poorly understood.
Caishang Zheng, Yanjun Wei, Qiang Zhang, Ming Sun, Yunfei Wang, Jiakai Hou, Peng Zhang, Xiangdong Lv, Dan Su, Yujie Jiang, J. Gumin, Nidhi Sahni, Baoli Hu, Wenyi Wang, Xi Chen, D. McGrail, Chaolin Zhang, Suyun Huang, Han Xu, Junjie Chen, F. Lang, Jian Hu, Yiwen Chen   +22 more
semanticscholar   +1 more source

LncRNA CACNA1G-AS1 up-regulates FTH1 to inhibit ferroptosis and promote malignant phenotypes in ovarian cancer cells

Oncology Research, 2023
Previous study revealed that ferritin heavy chain-1 (FTH1) could regulate ferritinophagy and affect intracellular Fe2+ content in various tumors, while its N6-methyladenosine (m6A) RNA methylation was closely related the prognosis of ovarian cancer ...
Yanping Jin, Jianping Qiu, Xiu-ming Lu, Yan Ma, Guowei Li   +4 more
semanticscholar   +1 more source