Results 1 to 10 of about 566 (113)

Urban PM2.5 Induces Cellular Toxicity, Hormone Dysregulation, Oxidative Damage, Inflammation, and Mitochondrial Interference in the HRT8 Trophoblast Cell Line [PDF]

Frontiers in Endocrinology, 2020
Objective: Epidemiological studies have found air pollution to be a driver of adverse pregnancy outcomes, including gestational diabetes, low term birth weight and preeclampsia. It is unknown what biological mechanisms are involved in this process.
Åsa Nääv, Lena Erlandsson, Christina Isaxon, Eleonor Åsander Frostner, Johannes Ehinger, Moa K. Sporre, Annette M. Krais, Bo Strandberg, Thomas Lundh, Eskil Elmér, Ebba Malmqvist, Stefan R. Hansson   +11 more
doaj   +3 more sources

Cytokine and nitric oxide levels in patients with sepsis--temporal evolvement and relation to platelet mitochondrial respiratory function. [PDF]

PLoS ONE, 2014
The levels of nitric oxide (NO) and various cytokines are known to be increased during sepsis. These signaling molecules could potentially act as regulators and underlie the enhancement of mitochondrial function described in the later phase of sepsis ...
Fredrik Sjövall, Saori Morota, Eleonor Åsander Frostner, Magnus J Hansson, Eskil Elmér   +4 more
doaj   +6 more sources

Correlation of mitochondrial respiration in platelets, peripheral blood mononuclear cells and muscle fibers [PDF]

Heliyon
There is a growing interest for the possibility of using peripheral blood cells (including platelets) as markers for mitochondrial function in less accessible tissues.
Emil Westerlund, Sigurður E. Marelsson, Michael Karlsson, Fredrik Sjövall, Imen Chamkha, Eleonor Åsander Frostner, Johan Lundgren, Vineta Fellman, Erik A. Eklund, Katarina Steding-Ehrenborg, Niklas Darin, Gesine Paul, Magnus J. Hansson, Johannes K. Ehinger, Eskil Elmér   +14 more
doaj   +3 more sources

Mitochondrial respiration in human peripheral blood mononuclear cells: methodology and influence of permeabilization and storage [PDF]

Frontiers in Molecular Biosciences
Human peripheral blood mononuclear cells (PBMCs) can be easily sampled from healthy individuals and patients. Density gradient isolation from human blood or leukocyte concentrates yields a mononuclear cell population of mainly lymphocytes, monocytes, and
Shusuke Sekine, Shusuke Sekine, Imen Chamkha, Evelina Elmér, Evelina Elmér, Eleonor Åsander Frostner, Emil Westerlund, Emil Westerlund, Tianshi Liu, Johannes Ehinger, Johannes Ehinger, Fredrik Sjövall, Fredrik Sjövall, Hiroyuki Uchino, Eskil Elmér, Eskil Elmér   +15 more
doaj   +3 more sources

Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production [PDF]

Intensive Care Medicine Experimental, 2018
Background Metformin is the most common pharmacological treatment for type 2 diabetes. It is considered safe but has been associated with the development of lactic acidosis under circumstances where plasma concentrations exceed therapeutic levels ...
Sarah Piel, Johannes K. Ehinger, Imen Chamkha, Eleonor Åsander Frostner, Fredrik Sjövall, Eskil Elmér, Magnus J. Hansson   +6 more
doaj   +3 more sources

Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency [PDF]

Nature Communications, 2016
Mitochondrial complex I deficiency is the most common respiratory chain defect in mitochondrial disease in children and currently there is no effective treatment.
Johannes K. Ehinger, Sarah Piel, Rhonan Ford, Michael Karlsson, Fredrik Sjövall, Eleonor Åsander Frostner, Saori Morota, Robert W. Taylor, Doug M. Turnbull, Clive Cornell, Steven J. Moss, Carsten Metzsch, Magnus J. Hansson, Hans Fliri, Eskil Elmér   +14 more
doaj   +3 more sources

Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene [PDF]

Acta Neuropathologica Communications, 2019
Variations in the POLG1 gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma, have recently been associated with Parkinson’s disease (PD), especially in patients diagnosed with progressive external ophthalmoplegia (PEO). However,
Margarita Chumarina, Kaspar Russ, Carla Azevedo, Andreas Heuer, Maria Pihl, Anna Collin, Eleonor Åsander Frostner, Eskil Elmer, Poul Hyttel, Graziella Cappelletti, Michela Zini, Stefano Goldwurm, Laurent Roybon   +12 more
doaj   +3 more sources

Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Amiodarone Toxicity. [PDF]

Int J Mol Sci, 2021
Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans. It has previously been demonstrated that amiodarone and its metabolite (desethylamiodarone, DEA) can inhibit mitochondrial function, particularly complexes I ...
Bețiu AM, Chamkha I, Gustafsson E, Meijer E, Avram VF, Åsander Frostner E, Ehinger JK, Petrescu L, Muntean DM, Elmér E.   +9 more
europepmc   +2 more sources

Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Statin Toxicity. [PDF]

Int J Mol Sci, 2021
Statins are the cornerstone of lipid-lowering therapy. Although generally well tolerated, statin-associated muscle symptoms (SAMS) represent the main reason for treatment discontinuation.
Avram VF, Chamkha I, Åsander-Frostner E, Ehinger JK, Timar RZ, Hansson MJ, Muntean DM, Elmér E.   +7 more
europepmc   +2 more sources

A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol. [PDF]

Alzheimers Res Ther
Background Combining multimodal lifestyle interventions and disease-modifying drugs (novel or repurposed) could provide novel precision approaches to prevent cognitive impairment.
Barbera M, Lehtisalo J, Perera D, Aspö M, Cross M, De Jager Loots CA, Falaschetti E, Friel N, Luchsinger JA, Gavelin HM, Peltonen M, Price G, Neely AS, Thunborg C, Tuomilehto J, Mangialasche F, Middleton L, Ngandu T, Solomon A, Kivipelto M, MET-FINGER study team.   +20 more
europepmc   +2 more sources