Results 101 to 110 of about 392,608 (388)

Aortic Coarctation: Recent Developments in Experimental and Computational Methods to Assess Treatments for this Simple Condition [PDF]

, 2010
Coarctation of the aorta (CoA) is often considered a relatively simple disease, but long-term outcomes suggest otherwise as life expectancies are decades less than in the average population and substantial morbidity often exists.
Feinstein, Jeffrey A., LaDisa, John F., Taylor, Charles A.   +2 more
core   +2 more sources

Lactate‐Activated GPR132‐Src Signal Induces Macrophage Senescence and Aggravates Atherosclerosis Under Diabetes

Advanced Science, EarlyView.
Elevated lactate in diabetes activates the GPR132‐Src pathway in macrophages, inducing macrophage senescence and further enhancing foam cell formation. This mechanism exacerbates atherosclerotic progression. Abstract Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various ...
Xiaofeng Ge, Shuying Wang, Zhaokai Li, Jing Yu, Binbin Liu, Ruiying Wang, Shichen Bu, Nawsher wan, Yan Wang, Cuilian Dai, Yijun Lin   +10 more
wiley   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

Management Peculiarities of Patients with Intramural Hematoma of the Ascending Aorta: a Clinical Case

Український журнал серцево-судинної хірургії, 2020
Intramural hematoma of the ascending aorta has been considered a rare form of an acute aortic syndrome, remaining a tremendous clinical problem in management paradigm. Purpose.
S. V. Varbanets, O. V. Telehuzova, Ye. O. Chernetskyi, A. S. Tsvyk   +3 more
doaj   +1 more source

The bicuspid aortic valve - studies on valve morphology and pathology in relation to ascending aortic dilatation and coronary artery disease [PDF]

, 2013
The prevalence of bicuspid aortic valve (BAV) is 1 - 2% and is thereby the most common cardiac malformation. BAV is highly associated with valvular dysfunction and aortic co nditions such as ascending aortic aneurysm and aortic ...
Jackson, Veronica
core   +1 more source

Giant aneurysm of the ascending aorta [PDF]

BMJ Case Reports, 2011
An ascending aortic aneurysm is a rare entity. The authors encountered an 85-year-old female patient with an uncomplicated ascending aortic aneurysm measuring 9 cm in diameter. She underwent an urgent operation involving replacement of the ascending aorta.
Vivek Srivastava, Palanikumar Saravanan, Mohamad N. Bittar, Joseph Zacharias, Kenda AlHadid   +4 more
openaire   +3 more sources

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

Advanced Science, EarlyView.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen   +18 more
wiley   +1 more source

Study of cardiovascular function using a coupled left ventricle and systemic circulation model [PDF]

, 2016
To gain insight into cardio-arterial interactions, a coupled left ventricle-systemic artery (LV–SA) model is developed that incorporates a three-dimensional finite-strain left ventricle (LV), and a physiologically-based one-dimensional model for the ...
Chen, W.W., Gao, H., Hill, N.A., Luo, X.Y.   +3 more
core   +1 more source

Surgery of the Ascending Aorta with or without Combined Procedures through an Upper Ministernotomy: Outcomes of a Series of More Than 100 Patients.

Annals of Thoracic and Cardiovascular Surgery, 2016
BACKGROUND Use of a minimally invasive approach for isolated aortic valve surgery is increasing. However, management of the root and/or ascending aorta through a mini-invasive incision is not so frequent.
S. Lentini, L. Specchia, S. Nicolardi, F. Mangia, Olivera Rasovic, G. Di Eusanio, R. Gregorini   +6 more
semanticscholar   +1 more source

Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin

Advanced Science, EarlyView.
Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang, Yabing Zhang, Zhiye Guo, He Ren, Weiyi Hu, Qingping Yao, Yunlong Huo, Yingxin Qi, Kai Huang   +8 more
wiley   +1 more source