Results 61 to 70 of about 3,657 (295)
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy
Advanced Science, EarlyView.By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng +16 more
wiley +1 more source
Modelo de ascite experimental [PDF]
, 1989 Orientador: Osvaldo MalafaiaCo-orientador: Clovis Eurico RohrigContem 7 fots. coladasDissertação (mestrado) - Universidade Federal do Parana, Setor de Ciencias da SaudeResumo: 0 objetivo do presente trabalho foi produzir ascite experimental em cães ...
Collaço, Iwan Augusto
core
Advanced Science, EarlyView.Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley +1 more source
Advanced Science, EarlyView.A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu +7 more
wiley +1 more source
Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling
Advanced Science, EarlyView.Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha +13 more
wiley +1 more source
Tuberculose péritonéale : quel outil diagnostique ?
Revue Malienne d’Infectiologie et de Microbiologie, 2014 INTRODUCTION : Le diagnostic de la tuberculose péritonéale reste difficile, surtout dans les pays où la prévalence de la maladie est faible. Malgré l'existence de nombreux moyens diagnostiques peu invasifs, le recours à la cœlioscopie est souvent ...
CAT Dabo +5 more
doaj +3 more sources
Estudo da ascite em doentes com cirrose hepática alcoólica.
Acta Médica Portuguesa, 1980 Estudou-se o líquido Ascítico (LA) de 56 doentes com Cirrose Hepática Alcoólica (CHA). 7 com ascite maligna e 5 com ascite de causa pancreática, com o objectivo de definir as suas características químicas ( proteínas, amilase, glucose e desidrogenase ...
J. Trindade +3 more
doaj +1 more source
Annals of Gastroenterological Surgery, EarlyView.This study aimed to determine the value of the National Clinical Database (NCD) risk calculator in predicting surgical outcomes and long‐term prognosis in patients undergoing resection for hepatocellular carcinoma (HCC). We retrospectively analyzed data from 210 patients with HCC who underwent initial hepatic resection, assessing the relationship ...
Mariko Tsukagoshi +8 more
wiley +1 more source