Results 131 to 140 of about 30,761 (293)
Advanced Science, EarlyView.This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu +10 more
wiley +1 more source
Ascorbic acid deficiency and hepatic UDP-glucuronyl transferase.
, 1989 The objective of this investigation was to determine the effect of dietary ascorbic acid on the important hepatic detoxifying enzyme, UDP-glucuronyltransferase.
Neumann, Catherine Mary
core
Glutathione and ascorbic acid protect Arabidopsis plants against detrimental effects of iron deficiency [PDF]
, 2019 Iron is an essential micronutrient required for a wide variety of cellular functions in plant growth and development. Chlorosis is the first visible symptom in iron-deficient plants.
Lamattina, Lorenzo +2 more
core
Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective
Advanced Science, EarlyView.Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok +4 more
wiley +1 more source
Advanced Science, EarlyView.An intracellular magneto‐mechanical platform utilizing MSC‐targeted nanomotors is developed. After intra‐articular delivery, these nanomotors target endogenous BMSCs and are actuated within lysosomes to execute trans‐planar rotational‐bouncing motions under a rotating‐fluctuating 3D magnetic field, generating amplified mechanical stimulation.
Zhenguang Li +7 more
wiley +1 more source
Advanced Science, EarlyView.Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu +20 more
wiley +1 more source
EXPERIMENTAL ATHEROSCLEROSIS WITH ASCORBIC ACID DEFICIENCY
Japanese Circulation Journal, 1971 FUJITANI, TAKAO +4 more
openaire +2 more sources
Advanced Science, EarlyView.This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun +14 more
wiley +1 more source
A rare cause of mental motor retardation: recessive congenital methemoglobinemia type II
The Turkish Journal of Pediatrics, 2009 Recessive congenital methemoglobinemia (RCM) is a very rare disorder caused by NADH- cytochrome b5 reductase (cytb5r) deficiency. It has been classified into four types.
Deniz Yüksel +4 more
doaj
Haemarthrosis Due to Ascorbic Acid Deficiency
International Journal of Clinical Practice, 1985 P T, Dawes, I, Haslock
openaire +2 more sources