Results 81 to 90 of about 30,761 (293)

An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids

open access: yesAdvanced Materials Technologies, EarlyView.
This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto   +6 more
wiley   +1 more source

An Unexpected Case of Scurvy in a Peritoneal Dialysis Patient

open access: yesCase Reports in Nephrology and Dialysis, 2017
This case describes an obese adult male peritoneal dialysis patient who presented with a pruritic follicular rash. Nutrient deficiency was not suspected initially in this case because there was no history of protein-calorie malnutrition, but the patient ...
Raymonda El Khoury   +3 more
doaj   +1 more source

Graphene‐Interfaced Stretchable Sweat Patch for Multiplexed Electrochemical Monitoring of IL‐6, Glucose, and Calcium Ions

open access: yesAdvanced Materials Technologies, EarlyView.
Flexible sweat sensor patch integrating graphene‑interfaced gold microelectrodes functionalized with bio‑receptors and ion‑selective membrane, coupled with a capillary‑driven microfluidic layer and portable potentiostat electronics for multiplexed monitoring of inflammatory, metabolic, and electrolyte biomarkers in microliter sweat volumes.
Roomia Memon   +4 more
wiley   +1 more source

Upcycling Compact Discs Into Ultra‐Stable, Flexible, and Stretchable Nanoporous Gold Electrodes for Enhanced Biosensing Performance

open access: yesAdvanced Materials Technologies, EarlyView.
This article highlights the development of robust and high‐performance flexible and stretchable biosensors that maintain long‐term functionality and optimal electrical conductivity under mechanical deformation, utilizing sustainable and cost‐effective manufacturing principles.
Mousa H. Aldosari, Ahyeon Koh
wiley   +1 more source

Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study. [PDF]

open access: yesAntioxidants (Basel), 2021
Clergue-Duval V   +13 more
europepmc   +1 more source

In Vitro Conversion of Desoxycortisol to Cortisol by Adrenal Tissues in Ascorbic Acid Deficiency

open access: yes, 1957
The influence of ascorbic acid nutrition on the ability of adrenal tissue to convert 11-desoxycortisol (compound S) to cortisol was studied. It was shown that this process of 11-beta-hydroxylation of desoxycortisol was decreased in ascorbic acid ...
Habeeb Bacchus
core   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

open access: yesAdvanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He   +17 more
wiley   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

open access: yesAdvanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao   +16 more
wiley   +1 more source

Genetic Determinants of Serum Ascorbic Acid Concentrations

open access: yes, 2011
Background: The adequacy of serum ascorbic acid (vitamin C) concentrations in young Canadian adults is unknown. Individuals have varied serum ascorbic acid response to dietary vitamin C, possibly due to genetic variation.
Cahill, Leah Elizabeth
core   +1 more source

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