Results 231 to 240 of about 20,771 (305)

Valproic Acid Inhibits Ferroptosis and Improves Bone Integration in OVX Rats Through the AMPK/SIRT1 Pathway

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The prevalence of postmenopausal osteoporosis (PMOP) has been steadily increasing. Ferroptosis has been recognized as a critical factor influencing the bone‐forming ability of bone marrow mesenchymal stem cells (BMSCs). Valproic acid (VPA), an HDAC inhibitor, has been suggested to play a role in regulating osteoporosis development; however ...
Qing‐Song Gu   +8 more
wiley   +1 more source

METTL14 Ameliorates Mitochondrial Dysfunction and Autophagy in Lens Epithelial Cells of Diabetic Cataracts via m6A Modification of RPL3

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li   +4 more
wiley   +1 more source

Unrestricted kinematic alignment on the sagittal plane: Posterior tibial slope and combined flexion do not have boundaries to respect in terms of short‐term clinical outcomes and safety

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Personalized alignment in total knee arthroplasty (TKA) is gaining traction as a surgical philosophy. True personalization, however, must encompass not only the coronal plane but also the sagittal and axial planes. This study evaluates influence of the Tibial Slope (PTS) and combined flexion (CF) on outcomes in TKA performed using ...
Edoardo Franceschetti   +9 more
wiley   +1 more source

Prior osteosynthesis—unlike osteotomy—raises revision risk after total knee arthroplasty, predominantly via periprosthetic infection

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Previous knee surgery is discussed as a risk factor for total knee arthroplasty (TKA), yet most reports do not distinguish between osteotomy and osteosynthesis. The German Operationen‐ und Prozedurenschlüssel (OPS)‐based classification was used to compare the impact of these procedures on implant survival, mortality and complications ...
Nele Wagener   +4 more
wiley   +1 more source

Comparison of Surgical Site Infections in Laparoscopic Versus Open Appendectomy: A Prospective Cohort Study. [PDF]

open access: yesCureus
Roghani AS   +7 more
europepmc   +1 more source

Younger age doubles medium‐term revision risk after total knee arthroplasty: A nationwide multicenter cohort of 5980 knees from the French SCORE I registry

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Although age is a known predictor of outcomes following total knee arthroplasty (TKA), most large‐scale studies rely on registry data that lack clinical detail and combines multiple implant designs. This study aimed to determine whether age has an independent effect on implant survivorship and clinical outcomes when a single TKA design
Alessandro Carrozzo   +5 more
wiley   +1 more source

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