Results 91 to 100 of about 172,598 (105)

Spurious Testosterone Laboratory Results in a Patient Taking Synthetic Alkaline Phosphatase (Asfotase Alfa)

Clinical Biochemistry, 2018
OBJECTIVES: We report a case of discordant total and free testosterone values in a patient with hypogonadism and juvenile hypophosphatasia after he initiated treatment with asfotase alfa, recombinant tissue non-specific alkaline phosphatase.
Eric T Rush, Whitney S Goldner
exaly   +2 more sources

Interference of Asfotase Alfa in Immunoassays Employing Alkaline Phosphatase Technology [PDF]

journal of applied laboratory medicine, The, 2020
BACKGROUND: Asfotase alfa (STRENSIQ®, Alexion Pharmaceuticals, Inc.) is the only approved treatment for patients with pediatric-onset hypophosphatasia, a disease caused by a mutation in the tissue-nonspecific alkaline phosphatase (TNSALP) gene.
Tompkins, Beatrice, Fraser, William Duncan, Piec, Isabelle Danielle   +2 more
exaly   +2 more sources

Monitoring Guidance for Patients With Hypophosphatasia Treated With Asfotase Alfa [PDF]

Molecular Genetics and Metabolism, 2017
Hypophosphatasia (HPP) is a rare, inherited, systemic, metabolic disorder caused by autosomal recessive mutations or a single dominant-negative mutation in the gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). The disease is associated with
Paul Harmatz, Craig F. Munns, Mark E Nuñes   +2 more
exaly   +2 more sources

Asfotase Alfa for Infants and Young Children With Hypophosphatasia: 7 Year Outcomes of a Single-Arm, Open-Label, Phase 2 Extension Trial [PDF]

Lancet Diabetes and Endocrinology,the, 2019
BACKGROUND: Our previous phase 2, open-label study of 11 infants and young children with life-threatening perinatal or infantile hypophosphatasia showed 1 year safety and efficacy of asfotase alfa, an enzyme replacement therapy.
Nicholas Bishop, Jill H. Simmons, Michael P. Whyte   +2 more
exaly   +2 more sources

Status Epilepticus Due to Asfotase Alfa Interruption in Perinatal Severe Hypophosphatasia

Pediatric Neurology, 2022
Hiroshi Yoshihashi, Eri Ogawa, Kazuhiro Shimura   +2 more
exaly  

Dental Outcomes for Children Receiving Asfotase Alfa for Hypophosphatasia

Bone, 2021
Cheryl Rockman-Greenberg, Robert J Schroth, Víctor H K Lee   +2 more
exaly  

Bone Healing and Reactivation of Remodeling Under Asfotase Alfa Therapy in Adult Patients With Pediatric-Onset Hypophosphatasia

Bone, 2021
Felix N Schmidt, Ralf Oheim, Florian Barvencik   +2 more
exaly  

Asfotase Alfa Treatment Improves Survival for Perinatal and Infantile Hypophosphatasia

Journal of Clinical Endocrinology and Metabolism, 2016
Nicholas Bishop, Cheryl Rockman-Greenberg, Keiichi Ozono   +2 more
exaly