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Asfotase alfa: Enzyme replacement for the treatment of bone disease in hypophosphatasia

Drugs of Today, 2016
Hypophosphatasia (HPP) is a rare disease caused by loss-of-function mutations in the tissue-nonspecific alkaline phosphatase (TNAP, TNSALP) gene. HPP causes a multisystemic syndrome with a predominant bone phenotype. The clinical spectrum ranges from high lethality in early onset (
C, Hofmann, L, Seefried, F, Jakob
openaire   +2 more sources

Asfotase-alfa

Reactions Weekly, 2023
openaire   +2 more sources

Ectopic Ocular Surface Calcification in Patients With Hypophosphatasia Treated With Asfotase Alfa

Cornea, 2019
Purpose: To assess for ectopic ocular calcification in a series of patients with hypophosphatasia (HPP) treated with asfotase alfa, a recombinant tissue-nonspecific alkaline phosphatase. Methods: This is a retrospective analysis of subjects enrolled at Duke University Medical Center
Sidney M, Gospe   +5 more
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Asfotase-alfa

Reactions Weekly, 2022
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Asfotase-alfa

Reactions Weekly, 2021
openaire   +1 more source

Asfotase alfa

Reactions Weekly, 2019
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