Results 211 to 220 of about 4,699,148 (388)

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen   +12 more
wiley   +1 more source

Rates and drivers of mangrove deforestation in Southeast Asia, 2000–2012

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2015
D. Richards, D. Friess
semanticscholar   +1 more source

Anti‐Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Protein Corona, GP130 Interaction, and Transcriptomic Profile

open access: yesAdvanced Science, EarlyView.
SeNSs provide a biocompatible, anti‐inflammatory UC therapy. SeNSs form protein coronas enriched with AKT/PI3K/NF‐κB pathway proteins, suppress GP130 via hydrophobic interactions, and inhibit pro‐inflammatory cytokines. In DSS‐induced UC mice, SeNSs reduce inflammation, tissue damage, and disease activity by modulating cytokine, chemokine, and ...
Dingyi Shen   +5 more
wiley   +1 more source

Activity‐Selectivity Trends in Electrochemical Urea Synthesis: Co‐Reduction of CO2 and Nitrates Over Single‐Site Catalysts

open access: yesAdvanced Science, EarlyView.
In this work, a series of single‐site metal phthalocyanine catalysts (MPcs (M = Zn, Co, Ni, Cu, and Fe)) are screened to learn their activity‐selectivity relationship in the co‐reduction reaction of CO2 and nitrates toward urea formation, which can be significantly promoted by enhanced adsorption of *HOOCNO, reduced adsorptions of *N and *COOH, and ...
Qinglan Zhao   +11 more
wiley   +1 more source

External Debt and Macroeconomic Performance in Latin America and East Asia [PDF]

open access: yes
macroeconomics, Asia, East Asia, Latin America ...
Jeffrey D. Sachs
core  

A Novel OsMPK6‐OsMADS47‐PPKL1/3 Module Controls Grain Shape and Yield in Rice

open access: yesAdvanced Science, EarlyView.
OsMADS47 is identified as a key regulator governing rice grain morphology. Phosphorylation‐dependent regulation of its activity directs the development of slender versus round grains, modulating both yield and appearance. This mechanism bridges cellular signaling with transcriptional regulation, establishing a molecular framework for grain optimization.
Jingjing Fang   +9 more
wiley   +1 more source

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