Results 211 to 220 of about 1,109,782 (317)

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Social determinants of low fertility in Asia: a comparative review of trends in East, Southeast and South Asia. [PDF]

Lancet Reg Health West Pac
Jean Yeung WJ, Abalos JB.
europepmc   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Report on the 10th Asia-Oceania Mass Spectrometry Conference (AOMSC2025). [PDF]

Mass Spectrom (Tokyo)
Ishihama Y.
europepmc   +1 more source

Exploring the Impact of Demographic Factors on Economic and Sectoral Dynamics: A Comparative Study of Selected South Asian Countries

Bilal Tariq, Mazhar Abbas, Zabair Arshad, Khaja Shameem Mohammed Abdul, Nor Hasni Osman, Nura Abubakar Allumi, Mohd Kamarul Irwan Abdul Rahim, Mohd Rizal Razalli   +7 more
openalex   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990-2021: results from the Global Burden of Disease Study 2021. [PDF]

BMJ Public Health
Cao Z, Tong X, He L, Luo Y, Huang K, Li W, Niu H, Chen Q, Jiao L, Vollmer S, Thompson B, Geldsetzer P, Atun R, Bärnighausen T, Wang C, Yang T, Chen S.   +16 more
europepmc   +1 more source

Moving Out of Poverty: An inquiry into the inclusive growth in Asia

, 2015
Jonna P. Estudillo, Keijiro Otsuka
openalex   +1 more source

In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases

Advanced Science, EarlyView.
This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du, Zetao Dang, Baofeng Xu, Jiajun Xu, Dan Wang, Yuewei Zhang, Shoujun Zhu   +6 more
wiley   +1 more source

Diagnosis of Pediatric Inflammatory Bowel Disease (PIBD)-Implications for the Asia-Pacific Region: A Position Paper from the Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition PIBD Working Group. [PDF]

Pediatr Gastroenterol Hepatol Nutr
Malik R, Aw MM, Lee WS, Darma A, Tanpowpong P, Ukarapol N, Huang JG, Tran HN, Ni YH, for Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition (APPSPGHAN) Pediatric Inflammatory Bowel Disease (PIBD) Working Group.   +11 more
europepmc   +1 more source