Results 221 to 230 of about 7,071,777 (294)

Global, regional, and 204 countries burden of disease attributed to secondhand smoke-related COPD, 1990-2021: A secondary data analysis of the Global Burden of Disease Study 2021. [PDF]

Tob Induc Dis
Huang Q, Fu L, Ali S, Hou S, Wang K, Li R, Ao B, Huang Y.   +7 more
europepmc   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Cervical cancer in Eastern Europe and Central Asia: the first signs of progress?

The Lancet Primary Care
Silvia Ussai, Teymur Seyidov, Nerea Blanqué Catalina, Tamar Khomasuridze   +3 more
doaj   +1 more source

Global, regional, and national burden of preterm birth 1990 to 2023, with projections of prevalence to 2050. [PDF]

Front Public Health
Huang Q, Zhou Y, Li J, Song C, Du L, Yu C, Xu Y.   +6 more
europepmc   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Global Patterns and Trends in Lifetime Risks of Developing and Dying from Cancer, 1990-2021. [PDF]

Health Data Sci
Ji Z, Song Y, Li Z, Huang X, Zhai S, Liu Q, Zeng R, Han R, Xiao Y, Yang Y, Lin X, Zhang Q, Li X.   +12 more
europepmc   +1 more source

Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming

Advanced Science, EarlyView.
Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du, Zhixiang Niu, Yanfen Wang, Shirui Zhou, Youqing Yang, Xiang Wei, Haishan Niu, Yitao Zhang, Anquan Xia, Yali Liu, Yanbin Hao, Kai Xue, Bingfang Wu, Xinquan Zhao, Tandong Yao, Yiyu Chen   +15 more
wiley   +1 more source

Disparities in maternal and fetal health among ethnogeographic groups-a retrospective cohort study of 30,000 women from a middle eastern multiethnic maternity population. [PDF]

Front Glob Womens Health
Minisha F, Abu Yaqoub S, Khenyab N, Salama H, AlObaidly S, Aldewik N, Al Rifai H, Farrell T.   +7 more
europepmc   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Climate-Action Driven Emission Changes of Unintentional Persistent Organic Pollutants From Global Copper Industry. [PDF]

Glob Chall
Sun Y, Yang Q, Yun J, Yang Y, Yu H, Zheng M, Liu G.   +6 more
europepmc   +1 more source