Results 241 to 250 of about 3,102,263 (313)

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Versatile DNA Hydrogel‐Mediated Delivery of Ginsenoside‐Encapsulated Small Extracellular Vesicles to Boost Diabetic Wound Repair

Advanced Science, EarlyView.
This study presents a DNA hydrogel‐mediated delivery system, in which ginsenoside (GS) molecules are incorporated into small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSCs) and the formed complexes are then anchored in DNA hydrogels via aptamer‐CD63 affinity as “GS/sEV@DNAgels”, to improve diabetic wound repair.
Jianming Xing, Shuangyang Li, Yuning Wang, Xushuang Jia, Ruiting Lin, Xintong Liu, Dongxu Wang, Ning Cui, Peng Ji, Jiaqi Chen, Shengnian Wang, Guangzhe Li, Ye Teng, Da Liu, Ye Jin   +14 more
wiley   +1 more source

Bridging Evidence Gaps: South Asian and African Enrollment in Cardiovascular Clinical Trials. [PDF]

JACC Asia
Caceres-Loriga FM, Morais H.
europepmc   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Management of HFpEF in Asian Patients: Evidence from Major Trials on HFpEF Therapeutics. [PDF]

JACC Asia
Hung CL, Chiang CE, Yeh HI.
europepmc   +1 more source

How Xenophobia Shapes Political Party Support: Evidence from COVID-19 in Canada. [PDF]

Race Soc Probl
Tan V.
europepmc   +1 more source

The effectiveness of atropine 0.05% eye drops versus placebo on controlling myopia progression among school children in randomized controlled trials: a systematic review and meta analysis. [PDF]

BMC Ophthalmol
Gebreselassie MG, Tefera Betru K, Alemyahu W, Woldesemayat EM.   +3 more
europepmc   +1 more source

Associations between neighborhood socioeconomic status with depressive symptoms, and psychological distress among Asian American adults in New York City. [PDF]

Sci Rep
Shyamsunder S, Ramachandran D, Kim C, Singh J, Dan S, Srinivasan M, Palaniappan L, Yang E, Elfassy T.   +8 more
europepmc   +1 more source

Whole-Genome Resequencing Analysis Reveals the Local Ancestry and Selection of Kongshan Cattle. [PDF]

Biology (Basel)
Bai M, Yang K, Ma X, Bian C, Wang W, Yi J, Chen N, Lei C, Xia X.   +8 more
europepmc   +1 more source

Benefit Design and Potential Trade-offs of Medicare Advantage Affinity Plans for Asian Beneficiaries.

JAMA Netw Open
Ma Y, Hamed P, Stein RI, Abeyweera N, Orav EJ, Tsai TC, Figueroa JF.   +6 more
europepmc   +1 more source