Results 171 to 180 of about 599,496 (255)

Hepatocellular Carcinoma in Southeast Asian Americans: Epidemiologic Trends, Screening Challenges, and Policy Implications. [PDF]

Healthcare (Basel)
Orusa AM, Lohr AM, Abu-Zeinah KF, Sia IG, Ridgeway JL, Jatoi A, Tran NH.   +6 more
europepmc   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Assessing the influence of air pollution on cholelithiasis formation and blood lipid levels: A two-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Xu Z, Yu C, Feng Y, Wang J, Deng Z.
europepmc   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Mapping Three Decades of Research on Southeast Asian Ovalocytosis: A Bibliometric Analysis. [PDF]

Mediterr J Hematol Infect Dis
Helmi MAM, Abdullah NZ, Omar AM, Rahim NEHA, Talib NA.   +4 more
europepmc   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Multimodal Ultrasound-Guided Hybrid Endoscopic Therapy Averting Pouch Excision and Permanent Stoma in Crohn's Disease of the Pouch

Journal of Digestive Endoscopy
Partha Pal, Mohammad Abdul Mateen, Pradeep Rebala, Rajesh Gupta, Manu Tandan, D. Nageshwar Reddy   +5 more
doaj   +1 more source

Prevalence and age of diagnosis of neurodevelopmental conditions among Asian populations in Aotearoa New Zealand. [PDF]

J Neurodev Disord
Panther NK, Bowden N, Chu J, D'Souza S, Saha S, Thabrew H, McLay LK.   +6 more
europepmc   +1 more source

Design Principles of Electrocatalysts for Industrial‐Scale Water Electrolysis

Advanced Energy Materials, EarlyView.
This Review distills electrocatalyst design for industrial‐scale water electrolysis into integrated principles linking active‐site engineering, phase and lattice modulation, interfacial microenvironment regulation and mass‐transport control. By connecting catalyst families with HER/OER mechanisms and practical operating demands, it outlines pathways ...
Hong Tang, Cui Ce, John Wang
wiley   +1 more source

Race/ethnicity and burden of atrial fibrillation in adults with paroxysmal atrial fibrillation. [PDF]

NPJ Cardiovasc Health
Go A, Reynolds K, Yang J, Gupta N, Garcia E, Harrison TN, Liu T, Solomon M.   +7 more
europepmc   +1 more source