Results 81 to 90 of about 344,668 (257)

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin   +9 more
wiley   +1 more source

Key factors influencing post-diagnostic support and care planning for people with dementia from South Asian backgrounds: a systematic review of qualitative studies

open access: yesBMC Geriatrics
Background Dementia in minority ethnic groups is on the rise. South Asian people represent 9.3% of the UK population and are the largest minority ethnic (ME) group.
Pushpa Nair   +5 more
doaj   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

open access: yesAdvanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song   +9 more
wiley   +1 more source

Muscle plays a more superior role than fat in bone homeostasis: A cross-sectional study of old Asian people. [PDF]

open access: yesFront Endocrinol (Lausanne), 2022
Liu C   +8 more
europepmc   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

open access: yesAdvanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song   +9 more
wiley   +1 more source

How Ethnoracial Groups Spend Their Time

open access: yesRSF: The Russell Sage Foundation Journal of the Social Sciences
We know strikingly little about how time use varies across ethnoracial groups in the United States. We describe the daily lives of 210,586 White, Black, Hispanic, and Asian people in the nationally representative American Time Use Survey (2003–2019 ...
Sarah James, Elizabeth Wrigley-Field
doaj   +1 more source

Role of Lipoprotein(a) in Atherosclerotic Cardiovascular Disease in South Asian Individuals

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
South Asian individuals (SA), representing approximately one quarter of the global population, experience a disproportionately high burden of cardiovascular disease.
Darshan Patel   +12 more
doaj   +1 more source

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