Results 121 to 130 of about 25,534 (273)

Insights into Bioactive Molecules in Rhododendron tomentosum: From Metabolomics to Biological Applications. [PDF]

Biomolecules
Schiavone G, Imbimbo P, De Pascale S, Ferracane R, Caira S, Scaloni A, Troise AD, Monti DM, Rocco V, D'Esposito D, Monti MM.   +10 more
europepmc   +1 more source

Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib

British Journal of Clinical Pharmacology, EarlyView.
Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang, Yunlan Fang, Phillip Wang, Xiang Liu, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

Multi-Target Pharmacological Effects of Asiatic Acid: Advances in Structural Modification and Novel Drug Delivery Systems. [PDF]

Molecules
Dong X, Wang T, Gao C, Cui Y, Li L.
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Comprehensive metagenomic analysis of the giant panda's oral microbiome reveals distinct taxonomic and functional characteristics. [PDF]

Anim Microbiome
Xiao LF, Li Y, Lian H, Liu X, Wen Y, Chen X, Huang W, Li B, Luo L, Wang X, Tutt C, Zheng J, Wang VY, Shao NY.   +13 more
europepmc   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Antibacterial and antibiofilm activity of <i>Eucalyptus globulus</i> leaf extract, asiatic acid and ursolic acid against bacteria isolated from bovine mastitis. [PDF]

Front Vet Sci
Mezzasalma N, Spadini C, Spaggiari C, Annunziato G, Andreoli V, Prosperi A, Mochen L, Cavirani S, Grolli S, Taddei S, Costantino G, Cabassi CS.   +11 more
europepmc   +1 more source

Locating the Third World in Cultural Geography [PDF]

, 2000
Rajagopal, Balakrishnan
core   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Transfersomal delivery of <i>Centella asiatica</i> promotes efficient excision wound healing in rats. [PDF]

Drug Deliv
Lapmanee S, Bunwatcharaphansakun P, Phongsupa W, Namdee K, Suttisintong K, Asawapirom U, Ruktanonchai U, Wongchitrat P, Bhubhanil S, Maitarad P, Khongkow M.   +10 more
europepmc   +1 more source