Results 51 to 60 of about 25,534 (273)

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

Marx, Globalization, and the Falling Rate of Profit: A Critical Study. [PDF]

This paper argues that Marx’s views on globalization and its supposed inevitability underwent a substantial evolution and revision after the publication of the Communist Manifesto.
Miguel D. Ramirez
core  

Determination of polycyclic aromatic hydrocarbons in tea infusions samples by high performance liquid chromatography with fluorimetric detection [PDF]

, 2017
This study focuses on the contamination of 15 polycyclic aromatic hydrocarbons (PAHs) , recommended by the US Environmental Protection Agency, in 10 tea brands distributed in Italy.
Apriceno, Azzurra, Francesca Tortora, And, Girelli, Anna Maria, Tarola, Anna Maria   +3 more
core   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

State capitalism as Lazarus meets Loch Ness: Insights from the Asiatic mode of production. [PDF]

Environ Plan A, 2023
Whiteside H.
europepmc   +1 more source

A critical survey of recent research in Chinese economic history. [PDF]

China is a resilient dinosaur. In contrast with so many other great empires in Eurasia – the Egyptian, Roman, Byzantine, Arabian, Ottoman and Tsarist-Soviet – China has the longest history.
Deng, Kent
core   +1 more source

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

A DNA Tetrahedron Delivery Asiatic Acid to Reprogram Mitochondrial Metabolism for Promoting Bone Regeneration via STAT3 Phosphorylation

Advanced Science, EarlyView.
A hyaluronic acid methacrylate (HAMA) hydrogel incorporating DNA tetrahedrons loaded with Asiatic acid (TDN@AA) was developed. HM‐TDN@AA promotes angiogenesis of endothelial cells (ECs), inhibits osteoclastogenesis from bone marrow–derived macrophages (BMDMs), and enhances osteogenesis of mesenchymal stem cells (MSCs) via STAT3‐mediated mitochondrial ...
Yiwen Huang, Yiming Zhang, Yisheng Feng, Qixiang Yang, Beiyuan Gao, Haiyang Xu, Cheng Huang, Kaili Lin, Yuanzhi Xu, Peiqi Zhu   +9 more
wiley   +1 more source

Collaborative and competitive strategies in the variability and resiliency of large-scale societies in Mesoamerica [PDF]

, 2018
Examinations of the variation and duration of past large-scale societies have long involved a conceptual struggle between efforts at generalization and the unraveling of specific trajectories. Although historical particulars are critical to understanding
Acemoglu, Adams, Adger, Ahlquist, Armillas, Baker, Barlow, Barnhart, Berdan, Berdan, Blanton, Blanton, Blanton, Blanton, Blanton, Blanton, Blanton, Boettiger, Boix, Butzer, Calnek, Carballo, Carballo, Castells, Chase, Chase, Childe, Cobos, Coe, Cook, Cowgill, Crumley, Culbert, Cyphers, D'Altroy, Dahlin, Dubreuil, Eakin, Earle, Fargher, Fash, Fash, Fash, Feinman, Feinman, Feinman, Feinman, Feinman, Feinman, Feinman, Feinman, Feinman, Folan, Fuentes, Gillespie, Hassig, Haviland, Healan, Hirth, Hirth, Joyce, Kowalewski, Levi, Levine, Lope, Magnoni, Marcus, Marx, Mastache, Melis, Morris, Nassaney, Offner, Offner, Olson, Palerm, Peregrine, Plunket, Plunket, Pohl, Pool, Pool, Puche, Puche, Puche, Pérez, Rust, Sanders, Smith, Smith, Smith, Sterelny, Steward, Tourtellot, Trigger, Turchin, Turner, Uruñuela, Wade, Webster, Wilken, Wittfogel, Wright   +102 more
core   +1 more source