Results 71 to 80 of about 8,902 (215)

A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination

Disease Models & Mechanisms, 2014
Canavan disease is a leukodystrophy caused by mutations in the ASPA gene. This gene encodes the enzyme that converts N-acetylaspartate into acetate and aspartic acid.
Marina R. Carpinelli, Anne K. Voss, Michael G. Manning, Ashwyn A. Perera, Anne A. Cooray, Benjamin T. Kile, Rachel A. Burt   +6 more
doaj   +1 more source

Advances in cholesterol and lipoproteins detection for healthcare: A review

VIEW, Volume 7, Issue 3, June 2026.
Cholesterol is one of the main biomarkers related to the development of cardiovascular diseases. Its detection still relies on traditional methods of analysis, such as gas and liquid chromatographies. Detection of free cholesterol in saliva with redox or enzymatic sensors or detection of lipoproteins in blood with aptamer sensors are currently the most
Jacopo Giaretta, Somayeh Fardindoost, Azadeh Abdi, Kaveh Yazdani, Longfei Yin, Syamak Farajikhah, Mina Hoorfar, Fariba Dehghani   +7 more
wiley   +1 more source

Johtamista kehittämässä - Valmentavan otteen vahvistaminen Aspa Palveluissa [PDF]

Tämä opinnäytetyönä toteutettu tutkimuksellinen kehittämisprojekti kohdistui Aspa-säätiön tytäryhtiöön Aspa Palveluihin, jossa meneillään olevan strategiakauden keskeiseksi johtamisen viitekehykseksi on määritelty valmentava ja tavoitteellinen johtaminen.
Parkkinen, Jenni
core  

Computational cost of ASPA with RD.

, 2019
Computational cost of ASPA with RD.
Waheed Ur Rehman (7300328), Aziz Ud Din (7300331), Naveed Ahmad (2570878), Qazi Ejaz Ali (7300322), Abdul Haseeb Malik (7300325), Gauhar Ali (7300334)   +5 more
core   +1 more source

A Cúpula América do Sul-Países Árabes

Meridiano 47, 2017
O presente artigo busca realizar um balanço da Cúpula América do Sul – Países Árabes, realizada em Brasília nos dias 10 e 11 de maio de 2005.
AMADO LUIZ CERVO
doaj  

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn   +19 more
wiley   +1 more source

A cúpula de Brasília

Meridiano 47, 2017
O presente artigo busca delinear os rumos e as expectativas para a Cúpula América do Sul – Países Árabes, a ser realizada nos dias 10 e 11 de maio de 2005.
AMADO LUIZ CERVO
doaj  

Ultra‐wide band bowtie slot waveguide antenna array for SAR application

IET Microwaves, Antennas & Propagation, 2019
An ultra‐wide bandwidth, high‐efficiency, small‐size and low‐profile waveguide antenna is presented in this study. To extend the bandwidth without increasing the antenna size, the bowtie shape slot and the stepped square coaxial transition in a ridged ...
Nan Wang, Naiming Ou, Pei Wang, Robert Wang   +3 more
doaj   +1 more source

Stable β2‐Microglobulin–HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer‐Associated Epitopes

European Journal of Immunology, Volume 56, Issue 5, May 2026.
We investigated differences in peptide repertoire when β2‐microglobulin is fused to the HLA‐I heavy chain. We observed: (1) that immunopeptidomes changed in this condition, (2) an overall increased median IC50 of the entire peptide repertoire, and (3) a reduced presentation of cancer‐specific epitopes with a strong predicted binding affinity for HLA‐I.
Ana Barajas Molina, Yehor Horokhovskyi, Nicole Acuti, Yee Kien Chong, Meghna Phanichkrivalkosil, Sophie Siddons, Hassnae Afrache, Megan Maloney, Wai Tuck Soh, Tom Hofland, Callum Hall, Henning Urlaub, George Kassiotis, Juliane Liepe, Michele Mishto   +14 more
wiley   +1 more source

High-power ultrasound pretreatment for enhanced protein extraction from lupin flour: Impact on yield, anti-technological and anti-nutritional factors, and techno-functional properties

Ultrasonics Sonochemistry
Quality of lupin protein is considerably compromised by the presence of anti-nutritional (ANF), such as polyphenols, alkaloids and saponins and anti-technological factors (ATF), like polyphenols and fat.
Paola Navarro-Vozmediano, Esperanza Dalmau, Jose Benedito, Jose V. Garcia-Perez   +3 more
doaj   +1 more source