Results 11 to 20 of about 3,234 (87)

Elucidation of Sulforaphane-Mediated Effects on the Cellular Human Metabolome Using Metabolic Profiling. [PDF]

Mol Nutr Food Res
Sulforaphane (SFN) is an isothiocyanate derived from broccoli and is related to various health‐promoting effects. By using metabolic profiling on the hepatoblastoma cell line HepG2 several effects on pathways such as TCA cycle, urea cycle and redox metabolism through SFN were identified.
Bieß N, Humpf HU, Behrens M, Gerdemann A.   +3 more
europepmc   +2 more sources

Unprecedented Nitrite-Dependent Aromatic Amination to Synthesize 2,4-Diamino-3-Hydroxybenzoic Acid. [PDF]

Chembiochem
By comparing the biosynthetic gene clusters for natural products with 2,4‐diamino‐3‐hydroxybenzoic acid (2,4,3‐DAHBA) moiety and heterologous expression in Streptomyces albus, we identified nine genes required for the biosynthesis of 2,4,3‐DAHBA, including nitrite biosynthesis genes.
Kuwabara K, Katsuyama Y, Ohnishi Y.
europepmc   +2 more sources

Heterotrophic ammonia oxidation by <i>Alcaligenes</i> balances ROS generation and terminal electron transport. [PDF]

mLife
Abstract Heterotrophic nitrifiers are bacteria that aerobically oxidize ammonia in the presence of organic carbon sources, which differs from autotrophic nitrifiers that extract energy from ammonia oxidation for cell metabolism and growth. The physiological significance of heterotrophic ammonia oxidation remains unclear, even though this process has ...
Wang R, Wang X, Zhao Y, Zhao X, Wu T, Wang Y, Li R, Yao J, Jiang C, Qiu JG, Li DF, Liu SJ.   +11 more
europepmc   +2 more sources

Mechanistic Foundations of KRAS-Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment. [PDF]

Adv Sci (Weinh)
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Ma J, Fu S, Tan J, Han Y, Chen Y, Deng X, Shen H, Zeng S, Peng Y, Cai C.   +9 more
europepmc   +2 more sources

Combined Analysis of Transcriptome and Metabolome Explains the Differences in Pulp Color in Jackfruit. [PDF]

Plant Direct
ABSTRACT The pulp color of jackfruit reflects variations in its nutritional composition and influences market preference. We investigated the mechanism underlying pulp coloration through an integrated transcriptomic and metabolomic analysis of three jackfruit cultivars—light yellow “THA”, yellow “GTM”, and orange “YNH”.
Liang J, Ma X, Yi C, Zhou H, Wei Z, Tang X, Ye W, Tang H, Zhu P.   +8 more
europepmc   +2 more sources

Taxonomic and functional shifts in the microbiome of severely obese, prediabetic patients: Ketogenic diet versus energy‐matched standard diet

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1826-1835, March 2026.
Abstract Aims Obesity and type 2 diabetes mellitus (T2DM) are among the leading global health challenges of the 21st century. While caloric restriction remains the cornerstone of weight loss interventions, ketogenic diets (KD), characterised by low carbohydrate and high fat intake, have been shown to improve metabolic health partly by modulating the ...
June Stone, Afroditi Tripyla, Melanie C. Scalise, Maria L. Balmer, Lia Bally, Dominik M. Meinel   +5 more
wiley   +1 more source

Discrete and cell‐specific hypoxic responses in Arabidopsis roots resolved by single‐nuclei transcriptomics

New Phytologist, Volume 249, Issue 6, Page 2652-2667, March 2026.
Summary With the intensification of unpredictable flooding events because of global warming, there is a need to understand how root cells perceive and respond to oxygen deprivation. The use of high‐throughput single‐nuclei RNA‐sequencing (snRNA‐Seq) allows the examination of gene expression profiles in discrete cell types.
Robert D. Hill, Sean M. Robertson, Abir U. Igamberdiev, Mohammed M. Mira, Olivia Wilkins, Claudio Stasolla   +5 more
wiley   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, Volume 293, Issue 3, Page 781-805, February 2026.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source