Results 21 to 30 of about 3,234 (87)

Long‐Term Administration of Pueraria lobata Radix Ethanol Extract Enhances Growth by Modulating Antioxidant Defense and Inflammatory Responses in Juvenile Eels (Anguilla japonica)

Aquaculture Research, Volume 2026, Issue 1, 2026.
This study was aimed to determine the optimized extract for Pueraria lobata radix (PLR) and to evaluate the effects of PLR dietary supplementation in juvenile eels (Anguilla japonica). A 23 full factorial design used was to determine PLR, selecting extraction’s ethanol (EtOH) concentration, temperature, and time as factors.
Walimuni Randika Harshan Mendis, Tae-Ho Ahn, Jin Hyeok Jang, Byung-Cheul Jeong, Seunghan Lee, So Young Kang, Jun Cheul Ahn   +6 more
wiley   +1 more source

ZFPL1 Promotes Colorectal Cancer Progression by Stabilizing ASS1 to Drive the Urea Cycle and M2 Macrophage‐Mediated Metastatic Colonization

Advanced Science, Volume 12, Issue 46, December 11, 2025.
ScRNA‐seq reveals ZFPL1‐specific enrichment in malignant CRC cells. Mechanistically, ZFPL1 stabilizes ASS1 by blocking K57 ubiquitination, activating urea cycle metabolism to drive progression. ZFPL1 inhibition reprograms the TME by suppressing M2 macrophages polarization and promotion M1 macrophages, thereby inhibiting CRC liver metastasis ...
Xiangjun Qian, Chenxi Xie, Beilin Zhang, Hengsong Cao, Zhengqing Lu, Li Liu, Shipeng Dai, Xiaoqian Wang, Xiaokai Zhang, Feng Han, Yanyan Liu, Haibo Yu, Weiwei Tang, Jinxue Zhou, Xiaopei Hao   +14 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, Volume 58, Issue 11, November 2025.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background Cancer metabolism is a field focused on the unique alterations in metabolic pathways that occur in cancer cells, distinguishing them from the metabolic processes in normal cells. Methods An extensive review of the current literature on the metabolic adaptation of cancer cells was carried out in the current study. Results The rapidly
Jilsy M. J. Punnasseril, Abdul Auwal, Vinod Gopalan, Alfred King‐Yin Lam, Farhadul Islam   +4 more
wiley   +1 more source

Arctic Soil C and N Cycling Are Linked With Microbial Adaptations During Drought

Global Change Biology, Volume 31, Issue 9, September 2025.
To understand responses of Arctic microbial carbon and nitrogen cycling to climate change, we simulated a drought event in a laboratory experiment and tracked microbial gene expression and greenhouse gas emissions across increasing levels of drought.
Theis Thomsen, Morten Dencker Schostag, Anders Priemé, Jonathan Donhauser   +3 more
wiley   +1 more source

Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

Advanced Science, Volume 12, Issue 30, August 14, 2025.
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake, thereby inhibiting macrophage ferroptosis.
Rong Wang, Jianwei Zhu, Jinyi Zhou, Jinyang Li, Min Wang, Yuqi Wu, Danshan Zhao, Xiancheng Chen, Xiaoyuan Chen, Yuetong Wang, Jianhua Zou   +10 more
wiley   +1 more source

Design, Synthesis, and Molecular Evaluation of SNAr‐Reactive N‐(6‐Fluoro‐3‐Nitropyridin‐2‐yl)Isoquinolin‐3‐Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode

Archiv der Pharmazie, Volume 358, Issue 8, August 2025.
The ubiquitin‐specific protease 7 (USP7) catalyzes the removal of ubiquitin and protects substrate proteins from degradation. USP7 causes structural changes upon ubiquitin binding, making it particularly suitable for use in covalent targeting approaches. The development, synthesis, and biophysical screening of a series of mildly electrophilic compounds
Larissa N. Ernst, Jason Stahlecker, Finn Mier, Ricardo A. M. Serafim, Valentin R. Wydra, Benedikt Masberg, Simon J. Jaag, Cornelius Knappe, Michael Lämmerhofer, Thilo Stehle, Matthias Gehringer, Frank M. Boeckler   +11 more
wiley   +1 more source

Impaired nitrogenous waste clearance promotes hepatocellular carcinoma. [PDF]

Sci Adv
Han X, Shen J, Yan J, Tacke R, Dai W, Mao Q, Queen Daguplo H, Liu S, Islam A, Liu T, Koch MC, Lin RZ, Li H, Anthony T, Xie P, Zhang L, Gao S, Simon MC, Chen X, Yang J, Su X, Zong WX.   +21 more
europepmc   +1 more source