Results 251 to 260 of about 16,662 (295)

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Aspartate aminotransferase-to-platelet ratio index (APRI) for staging of fibrosis in adults with chronic hepatitis C. [PDF]

Cochrane Database Syst Rev
Dreytser E, Blyuss O, Mudrova A, Turankova T, Gurusamy KS, Pavlov CS.   +5 more
europepmc   +1 more source

Mechanism‐informed machine learning for individualized tacrolimus dose adjustment in the early post‐kidney transplant period

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus dosing in the early post‐kidney transplant period is challenging due to a narrow therapeutic index and substantial interindividual pharmacokinetic (PK) variability. This study aimed to develop and validate mechanism‐informed machine learning (ML) models to support individualized tacrolimus dosing during this critical period ...
Hui Yu, Zihan Qin, Logan S. Smith, Jeong M. Park, Hao‐Jie Zhu   +4 more
wiley   +1 more source

Predictive value of hepatic, hematological, and immunological markers and their temporal dynamics in chronic hepatitis B functional cure. [PDF]

Microbiol Spectr
Zeng J, Zheng C, Zheng Y, Xue X.
europepmc   +1 more source

Comparison of MR elastography, FibroScan and aspartate aminotransferase to platelets ratio index for the non-invasive assessment of liver fibrosis

, 2007
Laurent Huwart, Christine Sempoux, Najat Salameh, Jacques Jamart, Laurence Annet, Ralph Sinkus, Frank Peeters, Leon terBeek, Yves Horsmans, Bernard E. Van Beers   +9 more
openalex   +1 more source

Could carbonic anhydrase IX predict fetal growth restriction in early onset preeclampsia? [PDF]

Rev Assoc Med Bras (1992)
Ozgen G, Dincgez B.
europepmc   +1 more source

Association of liver biomarker values beyond current thresholds and negative clinical outcomes in primary biliary cholangitis: analysis of a real-world healthcare claims database. [PDF]

J Comp Eff Res
Ritter TE, Hanson CJ, Fernandes C, MacEwan JP, Zhao X, Parzynski CS, Mercer D, Ness E, Wheeler D, Kowdley KV, Mayne T.   +10 more
europepmc   +1 more source

Evaluation of Human Brucellosis Patients with Post-Treatment Standard Tube Agglutination Test Titers. [PDF]

Pathogens
Benli A, Ceylan AN.
europepmc   +1 more source

Establishment of the histopathologics scores from hepatic lesion and determination of the normal values of enzymes aspartate aminotransferase and creatine kinase in chickens

, 2008
Lucas Brunelli de Moraes
openalex   +1 more source