Results 281 to 290 of about 88,625 (333)

Harnessing Synergies between Combinatorial Microfluidics and Machine Learning for Chemistry, Biology, and Fluidic Design

Chemistry–Methods, EarlyView.
This review explores the synergy of combinatorial microfluidics and machine learning, highlighting their transformative impact on high‐throughput experimentation, closed‐loop reaction optimization, and autonomous platform development. Key applications in chemical synthesis, biological research, and microfluidic design are discussed, addressing ...
Suyash S. Damir, Julie Probst, Andrew deMello, Stavros Stavrakis   +3 more
wiley   +1 more source

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Diagenetic processes controlled by volcanic detritus of the Lower‐Middle Permian Shanxi and Shihezi sandstone formations, North Ordos Basin, China

The Depositional Record, EarlyView.
Comparisons of Lower‐Middle Permian Shanxi and Lower Shihezi formations from the North Ordos Basin reveal that different types and percentages of volcanic detritus induced by active magmatic cycles can significantly change diagenetic evolution and favourable reservoirs.
Yuanlan Tang, Wei Jiang, Xianfeng Tan, Long Luo, Eduardo Garzanti, Jon Gluyas, Xueqi Yan, Jianping Liu, Tao Lei, Xuejiao Qu, Jia Wang, Xin Yu   +11 more
wiley   +1 more source

Reassessing Antiplatelet Resistance in Ischemic Stroke: Addressing Key Gaps in Precision Medicine Research. [PDF]

CNS Neurosci Ther
Taha MA.
europepmc   +1 more source

Carbonate sedimentology: An evolved discipline

The Depositional Record, EarlyView.
Abstract Although admired and examined since antiquity, carbonate sediment and rock research really began with Charles Darwin who, during a discovery phase, studied, documented and interpreted their nature in the mid‐19th century. The modern discipline, however, really began after World War II and evolved in two distinct phases.
Noel P. James, Peir K. Pufahl
wiley   +1 more source

Mechanisms and recent advances in non-coding RNAs and RNA modifications in antiplatelet drug resistance. [PDF]

Front Genet
Ni P, Chen K, Xiang J, Shao H, Chen X, Chen Q, Wang L, Hao J, Huang X, Cao Q, Yang Y, Tan Q, Yang J, Li S.   +13 more
europepmc   +1 more source

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Barrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia, Mathias Hochgerner, Qingzhen Wei, Xian'ge Zhong, Jiucun Wang   +4 more
wiley   +1 more source

A novel technological conception of integrated large‐scale CO2 storage, water recovery, geothermal extraction, hydrogen production, and energy storage

Deep Underground Science and Engineering, EarlyView.
A holistic utilization system that integrates large‐scale CO2 storage, water recovery, heat extraction, hydrogen production, and energy storage is presented. The whole system can be further divided into upstream industries (CO2‐enhanced water recovery module), midstream industries (green‐hydrogen production module), and downstream industries (energy ...
Huiling Ci, Bing Bai, Tiancheng Zhang, Hongwu Lei   +3 more
wiley   +1 more source

Drug response testing for elective carotid artery stenting: Prevalence of non-response to aspirin and clopidogrel and influence on post-interventional occurrence of cerebral ischemia. [PDF]

Neuroradiol J
Yousefi F, Hasan D, De Beukelaer F, Ridwan H, Nikoubashman O, Wiesmann M, Weyland CS.   +6 more
europepmc   +1 more source