Results 11 to 20 of about 2,790,356 (269)

Adult Male Hypogonadism: A Laboratory Medicine Perspective on Its Diagnosis and Management

Diagnostics, 2023
Testosterone (T), the principal androgen secreted by the testes, plays an essential role in male health. Male hypogonadism is diagnosed based on a combination of associated clinical signs and symptoms and laboratory confirmation of low circulating T ...
Mark Livingston, Adrian H. Heald
doaj   +1 more source

Paratope plasticity determines anti-HER2 (4B5) antibody specificity

mAbs
The PATHWAY anti-HER2/neu (4B5) Rabbit Monoclonal Primary Antibody immunohistochemistry (IHC) assay is used to identify patients eligible for anti-HER2 targeted therapy.
P. Daniel Warren, Terry H. Landowski, Mark S. Dodson, Adnan Gulzar, John D. Palting, Erika Walker, Penny Towne, Margaret H. Smith   +7 more
doaj   +1 more source

Evaluation of a research use only (RUO) TIMP-1 assay for use with the automated Alinity i platform

Biochemistry and Biophysics Reports
Tissue inhibitor of metalloproteinase-1 (TIMP-1) binds matrix metalloproteinases to regulate extracellular matrix turnover; elevated TIMP-1 has been associated with liver fibrosis, tumor progression, and fibrotic heart disease.
Mark Anderson, Jessica Grieshaber, Jose Ortiz, Mekhi Baclig, Gina Pacenti, Joseph Munoz, Christine Rudolph, Kathy Otis, Josie Corby, John Prostko, Philip Hemken   +10 more
doaj   +1 more source

The Content and Size of Hyaluronan in Biological Fluids and Tissues

Frontiers in Immunology, 2015
Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by integral membrane synthases. The repeating sequence is perfectly homogeneous, and is the same in all vertebrate tissues and fluids.
Mary K. Cowman, Hong-Gee eLee, Kathryn L. Schwertfeger, James B. McCarthy, Eva A. Turley   +4 more
doaj   +1 more source

Evaluation of Host Protein Biomarkers by ELISA From Whole Lysed Peripheral Blood for Development of Diagnostic Tests for Active Tuberculosis

Frontiers in Immunology, 2022
Tuberculosis (TB) remains a significant global health crisis and the number one cause of death for an infectious disease. The health consequences in high-burden countries are significant.
Harriet N. Garlant, Kalaiarasan Ellappan, Matthew Hewitt, Prem Perumal, Simon Pekeleke, Nadina Wand, Jo Southern, Saka Vinod Kumar, Harish Belgode, Ibrahim Abubakar, Sanjeev Sinha, Seshadri Vasan, Noyal Mariya Joseph, Karen E. Kempsell   +13 more
doaj   +1 more source

RefCNV: Identification of Gene-Based Copy Number Variants Using Whole Exome Sequencing

Cancer Informatics, 2016
With rapid advances in DNA sequencing technologies, whole exome sequencing (WES) has become a popular approach for detecting somatic mutations in oncology studies.
Lun-Ching Chang, Biswajit Das, Chih-Jian Lih, Han Si, Corinne E. Camalier, Paul M. McGregor, Eric Polley   +6 more
doaj   +1 more source

New Modalities of 3D Pluripotent Stem Cell-Based Assays in Cardiovascular Toxicity

Frontiers in Pharmacology, 2021
The substantial progress of the human induced pluripotent stem cell (hiPSC) technologies over the last decade has provided us with new opportunities for cardiovascular drug discovery, regenerative medicine, and disease modeling.
Barbara Orsolits, Zsófia Kovács, János Kriston-Vizi, Béla Merkely, Gábor Földes, Gábor Földes   +5 more
doaj   +1 more source

Assaying mechanosensation [PDF]

WormBook, 2014
C. elegans detect and respond to diverse mechanical stimuli using neuronal circuitry that has been defined by decades of work by C. elegans researchers. In this WormMethods chapter, we review and comment on the techniques currently used to assess mechanosensory response. This methods review is intended both as an introduction for those new to the field
Martin, Chalfie, Anne C, Hart, Catharine H, Rankin, Miriam B, Goodman   +3 more
openaire   +2 more sources

Antimicrobial Use in the Animal Sector in Japan from 2011 to 2022

Antibiotics
Background/Objectives: Evaluating antimicrobial use (AMU) is essential in the investigation and implementation of antimicrobial resistance (AMR) prevention measures.
Yuta Hosoi, Mari Matsuda, Michiko Kawanishi, Saki Harada, Mio Kumakawa, Hideto Sekiguchi, Tetsuo Asai, Tatsuro Sekiya   +7 more
doaj   +1 more source

Development of a rapid and accurate CRISPR/Cas13-based diagnostic test for GII.4 norovirus infection

Frontiers in Microbiology, 2022
Genogroup II genotype 4 (GII.4) norovirus causes acute gastroenteritis in children, and its infection is more severe than that of other genotypes. Early and precise detection and treatment are critical for controlling its spread and reducing the severity
Lei Duan, Xiaohan Yang, Wenli Zhan, Yuan Tang, Mengru Wei, Keyi Chen, Pan Liu, Jia Xie, Changbin Zhang, Hongyu Zhao, Mingyong Luo   +10 more
doaj   +1 more source