Results 81 to 90 of about 1,446,209 (307)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The structure of basal body inner junctions from Tetrahymena revealed by electron cryo-tomography
The EMBO JournalThe cilium is a microtubule-based eukaryotic organelle critical for many cellular functions. Its assembly initiates at a basal body and continues as an axoneme that projects out of the cell to form a functional cilium.
Sam Li +7 more
doaj +1 more source
Generic long-range interactions between passive bodies in an active fluid
, 2017 Because active particles break time-reversal symmetry, a single non-spherical body placed in an active fluid generates currents. We show that when two or more passive bodies are placed in an active fluid these currents lead to long-range interactions ...
Baek, Yongjoo +4 more
core +3 more sources
Cajal body surveillance of U snRNA export complex assembly [PDF]
Journal of Cell Biology, 2010 Phosphorylated adaptor for RNA export (PHAX) is the key export mediator for spliceosomal U small nuclear RNA (snRNA) precursors in metazoa. PHAX is enriched in Cajal bodies (CBs), nuclear subdomains involved in the biogenesis of small ribonucleoproteins. However, CBs’ role in U snRNA export has not been demonstrated. In this study, we show that U snRNA
Suzuki, Tatsuya +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Rethinking the Body Mass Index Initiative [PDF]
, 2007 In February 2005, the Office for Education Policy published a fact sheet detailing Arkansans’ attitudes toward the Body Mass Index initiative (BMI) and found that the state was roughly divided on the issue.
McKenzie, Sarah C., Ritter, Gary W.
core +2 more sources
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Formation of the Terrestrial Planets from a Narrow Annulus
, 2009 We show that the assembly of the Solar System terrestrial planets can be successfully modelled with all of the mass initially confined to a narrow annulus between 0.7 and 1.0 AU.
Brad M. S. Hansen +20 more
core +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
A basal body microtubule singlet-to-doublet transition in Plasmodium male gametogenesis
Nature CommunicationsAxoneme assembly constitutes a pivotal process in male gametogenesis of Plasmodium. Plasmodium possesses a unique nuclear envelope-anchored basal body that templates axoneme assembly, distinct from the basal body that templates the axoneme of cilia or ...
Shuzhen Yang +8 more
doaj +1 more source