Results 41 to 50 of about 942,194 (293)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Investigating the Effects of Assembly Order on the Performance in Relation to Cognitive and Physical Demands Under Takt Time [PDF]
Mehran University Research Journal of Engineering and Technology, 2014 Assembly line operations generally involve physical and cognitive demanding tasks. Simultaneous performance under physical and cognitive demanding tasks may create physical and mental stresses.
Shakeel Ahmed Shaikh +2 more
doaj
Computational benchmark for fuel assembly of VVER-1000 using the Monte Carlo Serpent code [PDF]
Nuclear Technology and Radiation Protection, 2018 The use of a new Monte Carlo Serpent code for the calculation of water-cooled reactors is presented and a calculation scheme of the fuel assembly for VVER-1000 reactors developed.
Galchenko Vitaliy V. +2 more
doaj +1 more source
Randomized Fast Design of Short DNA Words
, 2005 We consider the problem of efficiently designing sets (codes) of equal-length DNA strings (words) that satisfy certain combinatorial constraints. This problem has numerous motivations including DNA computing and DNA self-assembly.
Kao, Ming-Yang +2 more
core +2 more sources
Galaxy formation with radiative and chemical feedback [PDF]
, 2015 Here we introduce GAMESH, a novel pipeline which implements self-consistent radiative and chemical feedback in a computational model of galaxy formation. By combining the cosmological chemical-evolution model GAMETE with the radiative transfer code CRASH,
de Bennassuti, M. +5 more
core +3 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Effect of enrichment of plate-type fuel assembly on fuel performance
He jishuBackgroundThe enrichment of nuclear fuel may significantly influence the fuel performance of a reactor.PurposeThis study aims to explore the effect of U3Si2-Al plate-type fuel enrichment on its performance,MethodsThe fuel performance analysis code BEEs ...
YUE Zhiying +7 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source