Results 51 to 60 of about 6,607,658 (283)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A global assembly line for cyanobactins [PDF]
Nature Chemical Biology, 2008 More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria.
Mohamed S, Donia +2 more
openaire +2 more sources
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Integrating Assembly Planning and Line Balancing Using Precedence Diagram [PDF]
Engineering and Technology Journal, 2009 Traditionally, assembly planning and assembly line balancing are considered astwo independent tasks. Assembly planning represents a fundamental step in the operationof a manufacturing system that involves product assembly while line balancingrepresents ...
Bushra Basheer Abdulhasan
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Application of Digitization Procedures of Production in Practice
Management Systems in Production Engineering, 2019 The paper addresses application of digitazation of production processes, which is part of organizational digitization, also known as Industry 4.0.
Sujová Erika +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Journal of Manufacturing and Materials ProcessingThis paper addresses the use of discrete-event simulation as a tool for optimizing the production process of an assembly line and identifying the potential for improving production efficiency.
Vladimír Kotrady +4 more
doaj +1 more source
REDESIGNING ASSEMBLY LINE BY APPLYING RANKED POSITIONAL WEIGHT AT HEAVY-INDUSTRIAL FACILITY
Spektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri, 2020 To meet customer demand, the company was faced with insufficient capacity problems caused by low efficiency and congestion on the assembly line. Recent data shows that there is an imbalance in the work process time between workstations.
Hery Hamdi Azwir +1 more
doaj +1 more source