Results 81 to 90 of about 3,076,828 (236)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
'n Bespreking oor lynbalanseringstegnieke
South African Journal of Business Management, 1976 The problem of balancing assembly lines has been studied by many researchers of operations management. Most of the analytical techniques developed have failed to provide a practical solution.
P. G. Steyn
doaj +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Balanceamento de linhas de montagem com uso de algoritmo genético para o caso de linhas simples e extensões [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Produção, Florianópolis, 2010.Neste trabalho foi realizada uma revisão sobre o problema de balanceamento de linha de montagem ...
Cristo, Ronaldo Lima de
core
Proceedings of the Conference on Production Systems and LogisticsThe variance that can be seen in manual assembly lines is characterized, for example, by different processing times for the variants. This variance results in time expanding effects that cannot be compensated by an optional sequence up to batch size 1 in
Haase, Paul +4 more
doaj +1 more source
Identifying transgene insertions in Caenorhabditis elegans genomes with Oxford Nanopore sequencing [PDF]
PeerJGenetically modified organisms are commonly used in disease research and agriculture but the precise genomic alterations underlying transgenic mutations are often unknown.
Paula E. Adams +6 more
doaj +2 more sources
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
ASSEMBLY LINE BALANCING in a CLOTHING COMPANY [PDF]
Annals of the University of Oradea: Fascicle of Textiles, Leatherwork, 2017 Assembly lines take the attention of researchers and companies because of its great effect on efficiency. Efficiency in assembly lines has an important role on cost and quality which are the basic fundamentals of competition.
HASNALCACI Kubra +2 more
doaj
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source