Results 41 to 50 of about 152,174 (303)

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Enhancing social skills through cooperative learning

The Journal for Transdisciplinary Research in Southern Africa, 2008
The National Curriculum Statement of South Africa envisages qualified and competent teachers to deal with the diversity of learners and their needs in the classroom.
M J Booysen, M M Grosser
doaj   +1 more source

Assertion, Lying, and Untruthfully Implicating

, 2018
This chapter explores the prospects for justifying the somewhat widespread, somewhat firmly held sense that there is some moral advantage to untruthfully implicating over lying. I call this the "Difference Intuition." I define lying in terms of asserting,
Pepp, Jessica,
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Supposition: No Problem for Bilateralism

Bulletin of the Section of Logic
In a recent paper, Nils Kürbis argues that bilateral natural deduction systems in which assertions and denials figure as hypothetical assumptions are unintelligible. In this paper, I respond to this claim on two counts.
Ryan Simonelli
doaj   +1 more source

Norms of Speech Acts

Studia Semiotyczne, 2023
DOI: https://doi.org/10.26333/sts.xxxvi2.02 This paper offers a systematic classification and characterization of speech acts and their norms. Recently, the normative approach has been applied to various speech acts, most notably to constatives.
Grzegorz Gaszczyk
doaj  

Assertion: An Introduction and Overview

, 2011
This chapter starts by discussing the origins of this book, which began at a conference on assertion held at the Arché Philosophical Research Centre, St Andrews, Scotland in June 2007.
Herman Cappelen, Cappelen, H, Brown, Jessica, Jessica Brown, Cappelen, Herman Wright, Cappelen, Herman, Brown, J, Brown, Jessica Anne   +7 more
core   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Assertion and Argument in Xenophanes

Archai: Revista de Estudos sobre as Origens do Pensamento Ocidental
It is a commonplace in our histories of Greek philosophy that the first thinker to fashion deductive arguments was Parmenides of Elea. One corollary of this view is that Ionian philosophers before Parmenides provided no arguments in support of their ...
James H. Lesher
doaj   +1 more source

Knowledge and Assertion: A Critique of Lackey

European Journal of Analytic Philosophy, 2020
In the literature on assertion, there is a common assumption that having the knowledge that p is a sufficient condition for having the epistemic right to assert that p—call this the Knowledge is Sufficient for Assertion Principle, or KSA. Jennifer Lackey
Joshua Anderson
doaj   +1 more source