Results 141 to 150 of about 14,098,287 (316)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
An overview of the hydrology of the Zayandeh Rud Basin [PDF]
River basins / Hydrology / Water use / Reservoirs / Water balance / Climate / Irrigation systems / Iran / Esfahan Province / Zayandeh Rud Basin / Chadegan ...
Mamanpoush, A. +3 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
International Journal for Equity in HealthBackground Over the past two decades, Chile has undertaken numerous initiatives to reform its healthcare system. However, health equity is influenced by factors beyond the healthcare system.
Francesca Scandurra +3 more
doaj +1 more source
A dialogical approach to developing professional competence in assessment [PDF]
, 2012 Improving the students learning experience is closely connected with the promotion an implementation of an assessment strategy whose effectiveness relies on the quality of the formative aspect.
Lorenzi, Francesca, Rami, Justin
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Improving water productivity: how do we get more crop from every drop [PDF]
Water management / Productivity / Irrigation management / Supplemental irrigation / Crop ...
International Water Management Institute (IWMI) / Comprehensive Assessment of Water Management in Agriculture
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Self-Assessment: One of Ways Attaining Students\u27 Target Language in Autonomous Learning [PDF]
, 2017 This paper introduces the steps in developing students\u27 self-assessment in autonomous learning. Self-assessment is used as reflection students\u27 knowledge and understanding and also to motivate students to learning independently.
Wahyuningsih, S. K. (Sungkawati)
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source