Results 71 to 80 of about 333,852 (304)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Mediating Effect of Self-Efficacy on the Relationship Between Medication Literacy and Medication Adherence Among Patients With Hypertension

Frontiers in Pharmacology, 2020
Background: Studies have reported that medication literacy had a positive effect on medication adherence in patients with hypertension. However, little is known about the mechanism underlying this relationship in patients with hypertension.Objective: The
Zhiying Shen, Zhiying Shen, Zhiying Shen, Shuangjiao Shi, Shuangjiao Shi, Siqing Ding, Siqing Ding, Zhuqing Zhong, Zhuqing Zhong   +8 more
doaj   +1 more source

Older people and medication taking behaviour: A review of the literature [PDF]

, 2008
Background: Older people represent a sizeable population of the UK. Many older people receive drug treatment for long term conditions. Adherence with medication is therefore an important clinical, financial and resource intensive concern.
Barber, Belcher, Benson, Benson, Blaxter, Bonner, Butler, Campbell, Carr, Chen, Chin, Cline, Cohen, Conrad, Corlett, De Geest, Dowell, Dunbar-Jacob, Ekman, Griffiths, Harrison, Hughes, Johnson, Kippen, Kjellgren, Kjellgren, Kripalani, Lee, Leventhal, Levy, Lumme-Sandt, Maggi Banning, Maidment, Mallion, Mancia, Mays, McElnay, Phatak, Pound, Pound, Roth, Sackett, Salas, Sale, Scotto, Senior, Struthers, Svensson, Unson, Van der Wal, Veehof, Vermiere, Watson, Zafran   +53 more
core   +1 more source

Assessing Medication Adherence as a Standard of Care in Pediatric Oncology [PDF]

Pediatric Blood & Cancer, 2015
Poor adherence to pediatric cancer treatment protocols may prevent children and adolescents from realizing the potential benefits of therapy. This paper presents the evidence for a standard of care for supporting medication adherence. Databases were reviewed for articles examining adherence and including children and/or adolescents with cancer ...
Ahna L H, Pai, Meghan E, McGrady
openaire   +2 more sources

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The AdHOC study of older adults’ adherence to medication in 11 countries [PDF]

, 2005
BACKGROUND: Compared with the resources expended developing, evaluating and making clinical decisions about prescribing medication, we know little about what determines whether people take it. Older adults are prescribed more medication than any other
Carpenter, I., Cooper, C., Fialova, D., Katona, C., Livingston, G., Schroll, M., Wagner, C.   +6 more
core   +1 more source

Motivational Interviewing Impact on Cardiovascular Disease [PDF]

, 2020
: Harm reduction in cardiovascular disease is a significant problem worldwide. Providers, families, and healthcare agencies are feeling the burdens imparted by these diseases.

core  

Qualitative evaluation of adherence therapy in Parkinson’s disease: a multidirectional model [PDF]

, 2015
Background: Medication can control the symptoms of Parkinson’s disease (PD). Despite this, non-adherence with medication is prevalent in PD. Treatments for improving adherence with medication have been investigated in many chronic conditions, including ...
Daley, David, Deane, Katherine, Gray, Richard, Hill, Rebekah, Myint, Phyo   +4 more
core   +2 more sources