Results 41 to 50 of about 37,619,125 (281)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Harnessing local strengths: Asset-based community development and sustainable livelihoods in South Africa

Inkanyiso
This qualitative study explores the challenges in implementing community development interventions in South Africa using asset-based community development (ABCD) and sustainable livelihood (SL) frameworks.
Rebecca M. Skhosana
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Empowering Students Through Increasing Santriprenuer Knowledge

Amalee
Islamic boarding schools are required to be agents of development, playing an active role in contributing to and transforming the field of economic empowerment and the quality of their resources.
Muhammad Noor Fuady, Willy Ramadan, Muhammad Fahmi Nurani, Syatria Adymas Pranajaya   +3 more
doaj   +1 more source

A Two‐Stage Plasma Biomarker Algorithm Reduces Amyloid PET Use and the p‐Tau217 Gray Zone

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐Tau217 leaves 30%–50% of patients in an indeterminate “gray zone” often requiring Aβ‐PET. We developed GRAD (Gatekeeper‐Reflex for Alzheimer's Disease), a two‐stage Aβ‐positivity prediction model to improve classification while reserving Aβ‐PET for residual uncertainty.
Harthik Parankusham, Casey Vanderlip, Colin Birkenbihl, Eashwar Krishna, Chizobam Ugboaja, Andrew E. Budson, Brandon Frank, for the Alzheimer's Disease Neuroimaging Initiative   +7 more
wiley   +1 more source

A Case Study of Story Mapping, Neighborhood Change, and Community Assets of Ballpark, Salt Lake City

Land
Gentrification and displacement of low-income and minority families is a frequently discussed phenomenon when it comes to community planning. To best address and redistribute resources for these neighborhoods, needs assessments are often conducted to ...
Ivis García, Anthony Biamont, Jacob Klopfenstein   +2 more
doaj   +1 more source

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source

THE ENHANCEMENT OF THE CAPACITY OF COMMUNITIES AROUND THE FOREST IN PRODUCING ANIMAL FEED THROUGH SILAGE-MAKING TRAINING

Jurnal Layanan Masyarakat (Journal of Public Services)
Kemutug Lor Village, located on the southern slope of Mount Slamet, boasts various potentials, including livestock farming and the utilization of forest resources.
Budiyoko Budiyoko, Afduha Nurus Syamsi, Sunendar Sunendar, Lutfi Zulkifli, Malinda Rachmah, Abdulhakim Madiyoh   +5 more
doaj   +1 more source

Climate change vulnerability and resilience of urban poor in Khulna, Bangladesh: the role of asset-based community development approach

International Journal of Urban Sustainable Development, 2021
This article explores how the asset-based community development approach has improved the living conditions of the urban slum communities and have also addressed the house level poverty through direct asset transfer that can have positive co-benefits for
Md. Zakir Hossain, Md. Mostafizur Rahman
doaj   +1 more source