Results 111 to 120 of about 929,711 (254)

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

Towards Secure and Usable 3D Assets: A Novel Framework for Automatic Visible Watermarking [PDF]

arXiv
3D models, particularly AI-generated ones, have witnessed a recent surge across various industries such as entertainment. Hence, there is an alarming need to protect the intellectual property and avoid the misuse of these valuable assets. As a viable solution to address these concerns, we rigorously define the novel task of automated 3D visible ...
arxiv  

Targeting p21‐Positive Senescent Chondrocytes via IL‐6R/JAK2 Inhibition to Alleviate Osteoarthritis

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study uncovers a novel mechanism behind uneven cartilage degeneration in knee osteoarthritis (OA). Elevated IL‐6R expression activates the IL‐6 pathway, leading to SIRT1 degradation, chondrocyte senescence, and reduced SOX9 activity, which impairs cartilage matrix synthesis. Notably, the JAK inhibitor tofacitinib prevents IL‐6R‐mediated senescence,
Xiang Zhao, Jieming Lin, Feng Liu, Yu Zhang, Bo Shi, Chunhui Ma, Ziqi Wang, Song Xue, Qingrong Xu, Hongda Shao, Jingxing Yang, Yanzheng Gao   +11 more
wiley   +1 more source

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB Signaling

Advanced Science, EarlyView.
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran, Yideul Jeong, Suwoo Kim, Ji Eun Yeom, Jinwoo Lee, Wonhwa Lee, Gyu‐Un Bae, Jong‐Sun Kang   +7 more
wiley   +1 more source

The Cerebrospinal Fluid Secretion Rate Increases in Awake and Freely Moving Rats but Differs With Experimental Methodology

Advanced Science, Volume 12, Issue 17, May 8, 2025.
CSF dynamics are vital for neurological health. Yet accurate quantification of CSF rates is challenging. Using a novel technique in awake, freely moving rats, significantly higher secretion rates are found than in anesthetized rats. The findings highlight the importance of awake models and the adaptability of methods for studying CSF changes influenced
Trine L. Toft‐Bertelsen, Beatriche L. Edelbo, Annette B. Steffensen, Sara D. Lolansen, Jonathan H. Wardman, Dennis B. Jensen, Nanna MacAulay   +6 more
wiley   +1 more source

GNE‐317 Reverses MSN‐Mediated Proneural‐to‐Mesenchymal Transition and Suppresses Chemoradiotherapy Resistance in Glioblastoma via PI3K/mTOR

Advanced Science, Volume 12, Issue 12, March 27, 2025.
The study identifies MSN as a key regulator of proneural‐to‐mesenchymal transition (PMT) in GSCs, driving resistance to radiotherapy (RT) and temozolomide (TMZ) in glioblastoma (GBM). However, GNE‐317 specifically inhibits MSN, reverses PMT, resensitizes cells to therapy, and shows promise as a targeted strategy to overcome chemoradiotherapy resistance
Yong‐Chang Yang, Xing‐Yu Jin, Ling‐Ling Yang, Xing Xu, Yang Xie, Yi‐Ding Ai, Xin‐Chao Li, Ye‐Cheng Ma, Cheng‐Long Xu, Qi Li, Xiang‐Lian Ge, Tai‐Long Yi, Tao Jiang, Xiao‐Guang Wang, Ying‐Zhe Piao, Xun Jin   +15 more
wiley   +1 more source

Catheter Injectable Multifunctional Biomaterial for the Treatment of Infected Enterocutaneous Fistulas

Advanced Science, EarlyView.
A multi‐functional shear‐thinning hydrogel is engineered to treat enterocutaneous fistulas. This hydrogel can resist external pressures allowing it to remain within the fistula tract and is shown to have significant antimicrobial, pro‐healing, and anti‐inflammatory properties, which were validated in in vitro and in vivo experiments.
Jinjoo Kim, Zefu Zhang, Hassan Albadawi, Hyeongseop Keum, Joseph L. Mayer, Erin H. Graf, Rahmi Oklu   +6 more
wiley   +1 more source

A Model for Assessing Network Asset Vulnerability Using QPSO-LightGBM [PDF]

arXiv
With the continuous development of computer technology and network technology, the scale of the network continues to expand, the network space tends to be complex, and the application of computers and networks has been deeply into politics, the military, finance, electricity, and other important fields.
arxiv  

Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization

Advanced Science, EarlyView.
Occlusion of tumor blood vessels represents a promising yet challenging approach in cancer treatment. Herein, supramolecularly engineered platelets conjugated with morphology‐transformable nanoparticles is developed for precise tumor embolization. The engineered platelets actively accumulate at tumor sites following induced blood vessel injury.
Junyan Li, Ziyi Wang, Ruifeng Luo, Xingping Quan, Hong U Fong, Qian Cheng, Jianwen Wei, Leo Wang, Yonghua Zhao, Ruibing Wang   +9 more
wiley   +1 more source

On Quantum Ambiguity and Potential Exponential Computational Speed-Ups to Solving Dynamic Asset Pricing Models [PDF]

arXiv
We formulate quantum computing solutions to a large class of dynamic nonlinear asset pricing models using algorithms, in theory exponentially more efficient than classical ones, which leverage the quantum properties of superposition and entanglement. The equilibrium asset pricing solution is a quantum state.
arxiv