Results 241 to 250 of about 769,865 (316)

Effects of the Dietary Supplement 5α‐Hydroxy‐Laxogenin in the Orchiectomized Rat Model

open access: yesDrug Testing and Analysis, EarlyView.
The dietary supplement ingredient 5α‐hydroxy‐laxogenin was investigated in the castrated male rat for potential androgenic and anabolic effects. Moreover, androgen receptor binding of 5α‐hydroxy‐laxogenin was modelled by in silico docking. While molecular modelling supports androgen receptor binding, we observed neither androgenic nor anabolic effects ...
Daniel Derwand   +4 more
wiley   +1 more source

Characterising a New Cannabis Trend: Extensive Analysis of Semi‐Synthetic Cannabinoid‐Containing Seizures From Germany

open access: yesDrug Testing and Analysis, EarlyView.
A LC–MS/MS method has been validated for analysis of semi‐synthetic cannabinoids (SSC) and selected phytocannabinoids in seizures. Further SSC‐derivatives were implemented into the method for qualitative detection. The methodology was applied to a sample collective (n = 80) including cannabis flowers, resins, edibles and vape liquids.
Marica Hundertmark   +4 more
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal   +14 more
wiley   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li   +7 more
wiley   +1 more source

Development and Validation of Scalable Energy Models for Battery Cell Production Processes

open access: yesEnergy Technology, EarlyView.
Battery cell production is characterized by energy‐intensive processes that contribute significantly to the overall environmental impact of the battery life cycle. Therefore, this work describes process‐specific energy models for the different manufacturing steps. Validation and sensitivity analysis of the different models are presented together with a
Daniel Perez Clos   +5 more
wiley   +1 more source

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